Research Division, Hospital Juarez de Mexico, 07760, Mexico City, Mexico.
Biomedical Research Center, Fundacion Hospital Nuestra Señora de La Luz IAP, 06030, Mexico City, Mexico.
Sci Rep. 2022 Jan 10;12(1):329. doi: 10.1038/s41598-021-02554-y.
Vessel and perfusion densities may decrease before diabetic retinopathy appears; it is unknown whether these changes affect the contribution of vessel density to perfusion density. This was a non-experimental, comparative, prospective, cross-sectional study in non-diabetic subjects (group 1) and diabetics without retinopathy (group 2). Vessel and perfusion densities in the superficial capillary plexus were compared between groups at the center, inner, and full regions and by field (superior, temporal, inferior, nasal) using optical coherence tomography angiography. Coefficients of determination (R) between vessel and perfusion densities were calculated to find the contribution of larger retinal vessels to perfusion density. Percent differences were used to evaluate the contribution of these vessels to perfusion density in a regression model. There were 62 participants, 31 eyes by group; vessel and perfusion densities as well as the coefficients of determination between them were lower in group 2, especially in the nasal field (R 0.85 vs. 0.71), which showed a higher contribution of larger retinal vessels to perfusion density. The regression model adjusted to a quadratic equation. In diabetics without retinopathy the contribution of vessel density to perfusion density may decrease; a low vessel density may increase the contribution of larger retinal vessels to perfusion density.
血管和灌注密度可能在糖尿病视网膜病变出现之前就会降低；目前尚不清楚这些变化是否会影响血管密度对灌注密度的贡献。这是一项非实验性、对比性、前瞻性、横断面研究，纳入了非糖尿病患者（第 1 组）和无视网膜病变的糖尿病患者（第 2 组）。使用光相干断层扫描血管造影术比较了两组中心、内区和全区以及上方、颞侧、下方和鼻侧视野的浅层毛细血管丛的血管和灌注密度。计算了血管和灌注密度之间的决定系数（R），以发现较大视网膜血管对灌注密度的贡献。使用百分比差异在回归模型中评估这些血管对灌注密度的贡献。共有 62 名参与者，每组 31 只眼；第 2 组的血管和灌注密度以及它们之间的决定系数较低，尤其是在鼻侧视野（R 0.85 比 0.71），表明较大视网膜血管对灌注密度的贡献更高。回归模型调整为二次方程。在无视网膜病变的糖尿病患者中，血管密度对灌注密度的贡献可能会降低；低血管密度可能会增加较大视网膜血管对灌注密度的贡献。
