肽药物从具有不可逆凝胶化特性的可生物降解温度响应性注射水凝胶中的释放行为。

Peptide Drug Release Behavior from Biodegradable Temperature-Responsive Injectable Hydrogels Exhibiting Irreversible Gelation.

作者信息

Takata Kazuyuki, Takai Hiroki, Yoshizaki Yuta, Nagata Takuya, Kawahara Keisuke, Yoshida Yasuyuki, Kuzuya Akinori, Ohya Yuichi

机构信息

Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, 3-3-35 Yamate, Suita, Osaka 564-8680, Japan.

Organization for Research and Development of Innovative Science and Technology (ORDIST), Kansai University, Suita, Osaka 564-8680, Japan.

出版信息

Gels. 2017 Oct 15;3(4):38. doi: 10.3390/gels3040038.

We investigated the release behavior of glucagon-like peptide-1 (GLP-1) from a biodegradable injectable polymer (IP) hydrogel. This hydrogel shows temperature-responsive irreversible gelation due to the covalent bond formation through a thiol-ene reaction. In vitro sustained release of GLP-1 from an irreversible IP formulation () was observed compared with a reversible (physical gelation) IP formulation (). Moreover, pharmaceutically active levels of GLP-1 were maintained in blood after subcutaneous injection of the irreversible IP formulation into rats. This system should be useful for the minimally invasive sustained drug release of peptide drugs and other water-soluble bioactive reagents.