Center for Alcohol and Addiction Studies, Department of Behavioral and Social Science, Brown University, Providence, RI, USA.
Section on Clinical Psychoneuroendocrinology and Neuropsychopharmacology, National Institute on Alcohol Abuse and Alcoholism; and National Institute on Drug Abuse, National Institutes of Health, Bethesda, MD, USA.
Alcohol Alcohol. 2019 May 1;54(3):193-195. doi: 10.1093/alcalc/agz021.
There are limited functional magnetic resonance imaging (fMRI) studies that measure alcohol craving with multisensory environments. Researchers are faced with a two-fold challenge: to recreate a naturalistic environment during an MRI scan and to produce paradigms that mimic real-life conditions involved with craving. Craving is a multifaceted psychological construct and techniques such as fMRI provide an alternative way to measure craving and to have a better understanding of its complexity. Most studies to date have implemented visual stimuli to measure craving and only a few studies have investigated gustation and olfaction. Moving forward, there needs to be greater attention on the ways in which we measure craving and the use of multisensory environments during fMRI. By going beyond examining subjective craving responses, and investigating neurobiological responses such as brain activity during fMRI, can potentially lead to better treatments for alcohol use disorder. Further, there needs to be additional consideration on standardizing how we measure craving, which will allow for a more unified approach amongst researchers.
目前,使用多感觉环境测量酒精渴求的功能磁共振成像(fMRI)研究有限。研究人员面临着双重挑战:在 MRI 扫描期间重现自然环境,并设计出模拟与渴求相关的现实生活条件的范式。渴求具有多方面的心理结构,fMRI 等技术提供了一种衡量渴求的替代方法,有助于更好地理解其复杂性。迄今为止,大多数研究都采用视觉刺激来衡量渴求,只有少数研究调查了味觉和嗅觉。未来,我们需要更加关注衡量渴求的方法,以及在 fMRI 期间使用多感觉环境。通过超越对主观渴求反应的研究,调查 fMRI 期间的大脑活动等神经生物学反应,可能会为治疗酒精使用障碍提供更好的方法。此外,我们还需要更多地考虑如何标准化我们衡量渴求的方式,这将使研究人员能够采取更加统一的方法。