Colleoni N, D'Amico G
Nephron. 1986;44(1):32-5. doi: 10.1159/000183908.
Gout rarely develops in nephropathy with advanced renal failure unless other risk factors are present. It has recently been demonstrated that gouty patients with renal failure have greater amounts of mobilizable lead. We have used the EDTA lead mobilization test for 12 gouty patients with renal impairment. Only 7 of these had experienced occupational exposure to lead. 12 patients with nephropathy caused by chronic glomerulonephritis, without a history of gout or lead exposure, were selected as controls. The urinary excretion of lead after the mobilization test was significantly higher in gouty patients. Only in gouty patients was lead excretion directly correlated with the serum creatinine level. Thus, renal failure did not induce any increase in mobilizable lead. Since it is not infrequent in Italy to observe patients with a progressively declining renal function due to chronic interstitial nephritis and with a previous history of gout, we think the EDTA test will be useful to look for lead storage in these patients.
痛风很少在晚期肾衰竭的肾病中发生，除非存在其他危险因素。最近有研究表明，肾衰竭的痛风患者体内可动员的铅含量更高。我们对12例有肾功能损害的痛风患者进行了EDTA铅动员试验。其中只有7例有职业性铅接触史。选取12例由慢性肾小球肾炎引起的肾病患者作为对照，这些患者无痛风或铅接触史。痛风患者在动员试验后尿铅排泄量显著更高。只有痛风患者的铅排泄量与血清肌酐水平直接相关。因此，肾衰竭并未导致可动员铅的增加。由于在意大利，因慢性间质性肾炎导致肾功能逐渐下降且有痛风病史的患者并不少见，我们认为EDTA试验将有助于在这些患者中寻找铅储存情况。
