使用单聚分辨介质从全血中分离的111铟-奥克辛标记中性粒细胞的制备及其体内行为。
The preparation and in vivo behaviour of 111In-oxine labelled neutrophils separated from whole blood using mono-poly resolving medium.
作者信息
Bell D, Millar A M, McGillivray M, Muir A L
出版信息
Nucl Med Commun. 1986 Jun;7(6):447-53. doi: 10.1097/00006231-198606000-00007.
using a single step separation procedure, we have developed a method for labelling human neutrophils with 111In-oxine. This method allows a rapid separation of neutrophils from whole blood, with negligible mononuclear or red cell contamination. Preliminary studies using 111In-labelled neutrophils show minimal lung retention and early accumulation in the spleen consistent with viable cells. In addition, focal accumulation of 111In has been imaged in patients with localized inflammation or sepsis.
我们采用单步分离程序，开发了一种用铟 - 111奥克辛标记人中性粒细胞的方法。该方法能快速从全血中分离出中性粒细胞，单核细胞或红细胞污染可忽略不计。使用铟 - 111标记的中性粒细胞的初步研究表明，肺部滞留极少，且与活细胞一致地早期在脾脏中积聚。此外，铟 - 111在局部炎症或脓毒症患者中成像有局灶性积聚。
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