Banki C M, Arato M, Papp Z, Rihmer Z, Kovacs Z
Psychoneuroendocrinology. 1986;11(2):205-11. doi: 10.1016/0306-4530(86)90055-7.
TRH-induced thyrotropin (TSH), prolactin (PRL), and growth hormone (GH) responses were investigated together with a dexamethasone suppression test in female psychiatric inpatients with major melancholic depression (n = 21), schizophrenic disorder (n = 20), alcohol dependence (n = 11), and adjustment disorder with predominantly depressed mood (n = 13), as well as in 15 healthy women. Abnormal responses for all four endocrine variables were noted most frequently in melancholia; however, a significant number of the non-depressed patients also had abnormal hormonal responses in the individual test. The association of two or three abnormalities proved to be quite specific for the melancholic group. There were no statistically significant differences in TRH-induced TSH responses among the patient subgroups. Non-suppression of cortisol after dexamethasone was associated with blunted TSH-responses only in melancholia. There was a tendency for non-suppressor schizophrenics to show more abnormal GH-responses to TRH administration.
对患有重度忧郁性抑郁症（n = 21）、精神分裂症（n = 20）、酒精依赖（n = 11）和以抑郁情绪为主的适应障碍（n = 13）的女性精神科住院患者以及15名健康女性，研究了促甲状腺激素释放激素（TRH）诱导的促甲状腺激素（TSH）、催乳素（PRL）和生长激素（GH）反应，并同时进行了地塞米松抑制试验。在忧郁症患者中，最常观察到所有四种内分泌变量的异常反应；然而，相当数量的非抑郁症患者在个别试验中也有激素反应异常。两种或三种异常的关联被证明对忧郁症组具有相当的特异性。患者亚组之间TRH诱导的TSH反应无统计学显著差异。仅在忧郁症患者中，地塞米松后皮质醇不被抑制与TSH反应迟钝有关。非抑制性精神分裂症患者对TRH给药表现出更多异常GH反应的趋势。
