Banki C M, Arató M, Papp Z
Acta Psychiatr Scand. 1984 Oct;70(4):295-303. doi: 10.1111/j.1600-0447.1984.tb01212.x.
Fifteen healthy women and 64 female psychiatric inpatients (major depression: 17, schizophrenia: 24, alcohol dependence: 9, and adjustment disorder: 14 cases) without identifiable thyroid dysfunction were investigated with the TRH test under comparable circumstances. Although all patient groups showed some tendency toward lower baseline TSH and smaller TRH-induced TSH responses, only patients with major depression demonstrated marked, statistically significant differences from controls in both variables. Women with alcohol dependence (in the early withdrawal period) showed significantly decreased TSH responses to TRH but only a weak tendency to lower basal TSH levels. Intergroup differences in the TSH response remained significant after correction for basal TSH by analysis of covariance. Neither variables correlated significantly with age, weight or body height, but baseline TSH correlated with body surface. The TRH test, using only 0.2 mg TRH for stimulation, seemed to be useful for identifying major depression and showed that early withdrawal from alcohol may be a factor to be considered in similar studies.
在可比条件下，对15名健康女性和64名无明显甲状腺功能障碍的女性精神科住院患者（重度抑郁症：17例，精神分裂症：24例，酒精依赖：9例，适应障碍：14例）进行了促甲状腺激素释放激素（TRH）试验。尽管所有患者组在基线促甲状腺激素（TSH）较低和TRH诱导的TSH反应较小方面都有一定趋势，但只有重度抑郁症患者在这两个变量上与对照组存在显著的统计学差异。酒精依赖女性（处于早期戒断期）对TRH的TSH反应显著降低，但基础TSH水平仅呈微弱下降趋势。通过协方差分析对基础TSH进行校正后，TSH反应的组间差异仍然显著。这两个变量均与年龄、体重或身高无显著相关性，但基线TSH与体表面积相关。仅使用0.2mg TRH进行刺激的TRH试验似乎有助于识别重度抑郁症，并且表明在类似研究中，早期戒酒可能是一个需要考虑的因素。
