The Babraham Institute, Cambridge, UK.
J Exp Med. 2019 May 6;216(5):1010-1011. doi: 10.1084/jem.20190246. Epub 2019 Mar 28.
T cell tolerance depends upon Aire-expressing cells to purge the T cell repertoire of autoreactive clones. Once thought to be the exclusive domain of thymic epithelial cells, a new study by Yamano et al. (https://doi.org/10.1084/jem.20181430) in this issue of identifies ILC3-like cells in the lymph nodes with similar properties.
T 细胞耐受取决于表达 Aire 的细胞来清除 T 细胞库中的自身反应性克隆。曾被认为是胸腺上皮细胞的特有领域，Yamano 等人的一项新研究（https://doi.org/10.1084/jem.20181430）在本期杂志中鉴定出淋巴结中的 ILC3 样细胞具有类似的特性。
