AIRE的扩展：免疫耐受及其他方面的新作用。
AIRE expands: new roles in immune tolerance and beyond.
作者信息
Anderson Mark S, Su Maureen A
机构信息
Diabetes Center, University of California, San Francisco, San Francisco, California 94143, USA.
Departments of Pediatrics and of Microbiology/Immunology, School of Medicine, and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
出版信息
Nat Rev Immunol. 2016 Apr;16(4):247-58. doi: 10.1038/nri.2016.9. Epub 2016 Mar 14.
Abstract
More than 15 years ago, mutations in the autoimmune regulator (AIRE) gene were identified as the cause of autoimmune polyglandular syndrome type 1 (APS1). It is now clear that this transcription factor has a crucial role in promoting self-tolerance in the thymus by regulating the expression of a wide array of self-antigens that have the commonality of being tissue-restricted in their expression pattern in the periphery. In this Review, we highlight many of the recent advances in our understanding of the complex biology that is related to AIRE, with a particular focus on advances in genetics, molecular interactions and the effect of AIRE on thymic selection of regulatory T cells. Furthermore, we highlight new areas of biology that are potentially affected by this key regulator of immune tolerance.
摘要
15年多前，自身免疫调节因子（AIRE）基因的突变被确定为1型自身免疫性多腺体综合征（APS1）的病因。现在已经明确，这种转录因子通过调节多种自身抗原的表达，在促进胸腺中的自身耐受方面发挥着关键作用，这些自身抗原在外周组织中的表达模式具有组织限制性。在本综述中，我们重点介绍了我们对与AIRE相关的复杂生物学的许多最新认识进展，特别关注遗传学、分子相互作用以及AIRE对调节性T细胞胸腺选择的影响方面的进展。此外，我们还强调了可能受这种免疫耐受关键调节因子影响的新生物学领域。
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