Collins M S, Tsay G C, Hector R F, Roby R E, Dorsey J H
Rev Infect Dis. 1986 Jul-Aug;8 Suppl 4:S420-5. doi: 10.1093/clinids/8.supplement_4.s420.
Mice with cyclophosphamide-induced neutropenia were challenged with four immunotypes of Pseudomonas aeruginosa by contamination of a small dorsal surface wound. The infections were lethal; 100% of control animals (n = 80) treated only with albumin died. Administration of an immunoglobulin G intravenous preparation (IGIV) and/or therapy with tobramycin or azlocillin was begun 16 hr after challenge. Mortality among mice (n = 120) treated only with an antibiotic was 75.0%, while that among mice (n = 80) treated only with IGIV was 78.8%. Combination therapy with IGIV and an antibiotic (n = 120) resulted in mortality of 38.3%. The protection afforded by IGIV may have resulted in part from neutralization of exotoxin A, as mice treated with IGIV before challenge with exotoxin A were subject to lower mortality and had lower levels of serum aspartate and alanine aminotransferases than controls.
通过污染小鼠背部小伤口，用四种免疫型铜绿假单胞菌对环磷酰胺诱导的中性粒细胞减少症小鼠进行攻击。这些感染是致命的；仅用白蛋白治疗的100%对照动物（n = 80）死亡。攻击后16小时开始给予静脉注射免疫球蛋白G制剂（IGIV）和/或用妥布霉素或阿洛西林治疗。仅用抗生素治疗的小鼠（n = 120）死亡率为75.0%，而仅用IGIV治疗的小鼠（n = 80）死亡率为78.8%。IGIV与抗生素联合治疗（n = 120）导致死亡率为38.3%。IGIV提供的保护可能部分归因于外毒素A的中和作用，因为在接受外毒素A攻击前用IGIV治疗的小鼠死亡率较低，且血清天冬氨酸和丙氨酸转氨酶水平低于对照组。
