细胞外基质蛋白ABI3BP在心血管健康与疾病中的作用
The Extracellular Matrix Protein ABI3BP in Cardiovascular Health and Disease.
作者信息
Delfín Dawn A, DeAguero Joshua L, McKown Elizabeth N
机构信息
Department of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico, Albuquerque, NM, United States.
出版信息
Front Cardiovasc Med. 2019 Mar 14;6:23. doi: 10.3389/fcvm.2019.00023. eCollection 2019.
Abstract
ABI3BP is a relatively newly identified protein whose general biological functions are not yet fully defined. It is implicated in promoting cellular senescence and cell-extracellular matrix interactions, both of which are of vital importance in the cardiovascular system. ABI3BP has been shown in multiple studies to be expressed in the heart and vasculature, and to have a role in normal cardiovascular function and disease. However, its precise role in the cardiovascular system is not known. Because ABI3BP is present in the cardiovascular system and is altered in cardiovascular disease states, further investigation into ABI3BP's biological and biochemical importance in cardiovascular health and disease is warranted.
摘要
ABI3BP是一种相对较新发现的蛋白质，其一般生物学功能尚未完全明确。它与促进细胞衰老和细胞与细胞外基质的相互作用有关，这两者在心血管系统中都至关重要。多项研究表明，ABI3BP在心脏和血管系统中表达，并在正常心血管功能和疾病中发挥作用。然而，其在心血管系统中的精确作用尚不清楚。由于ABI3BP存在于心血管系统中，且在心血管疾病状态下会发生改变，因此有必要进一步研究ABI3BP在心血管健康和疾病中的生物学和生化重要性。
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