Department of Dermatology, Sanggye Paik Hospital, Inje University, Seoul, Korea.
J Cosmet Dermatol. 2019 Dec;18(6):1717-1720. doi: 10.1111/jocd.12920. Epub 2019 Mar 28.
Latanoprost is a prostaglandin F2α analogue, which has been used as a first-line drug for open-angle glaucoma. Common side effects of latanoprost include hyperpigmentation. While it usually occurs on irides or periocular skin, diffuse facial hyperpigmentation is rarely reported.
A 71-year-old woman was presented with diffuse gray-brown colored maculopatches on her face. The symptom appeared 1 week after she started to use latanoprost eye drops for glaucoma. Biopsy specimen revealed vacuolar degeneration of dermo-epidermal junction and pigment incontinence in dermis.
The aim of this paper is to introduce a rare adverse effect of latanoprost and effective way of treatment.
We stopped her from using latanoprost. She was also treated with 532-nm potassium titanyl phosphate laser and low-fluence 1064-nm Q-switched Nd:YAG laser, while using topical agents.
After 10 weeks, we observed hyperpigmentation of her face was effectively and safely treated. The patient was satisfied with the result.
Diffuse facial pigmentation could be one of the latanoprost-induced adverse effects and the laser treatments with topical agents we used can make it improve faster.
拉坦前列素是一种前列腺素 F2α 类似物，已被用作开角型青光眼的一线药物。拉坦前列素的常见副作用包括皮肤色素沉着。虽然它通常发生在虹膜或眼周皮肤，但弥漫性面部色素沉着很少见。
一名 71 岁女性因面部出现弥漫性灰棕色斑片状斑块就诊。该症状出现在她开始使用拉坦前列素滴眼液治疗青光眼后 1 周。活检标本显示真皮表皮连接的空泡变性和真皮内色素失禁。
本文旨在介绍拉坦前列素的一种罕见不良反应及其有效治疗方法。
我们停止了她使用拉坦前列素。她还接受了 532nm 掺钛蓝宝石激光和低能量 1064nm Q 开关 Nd:YAG 激光治疗，同时使用局部药物。
10 周后，我们观察到她面部的色素沉着得到了有效和安全的治疗。患者对结果满意。
弥漫性面部色素沉着可能是拉坦前列素引起的不良反应之一，我们使用的激光治疗联合局部药物治疗可使其更快改善。
