Department of Paediatrics and Child Health, University of Otago, Wellington, New Zealand.
Department of , Medicine, University of Otago, Wellington, New Zealand.
Pediatr Pulmonol. 2019 Jun;54(6):865-872. doi: 10.1002/ppul.24276. Epub 2019 Mar 28.
The aims of this study were to: (i) Determine in preterm infants at neonatal discharge the prevalence of intermittent hypoxia (IH), as measured by the oxygen desaturation index (DSI) recorded by pulse oximetry and (ii) Determine the change in values for very preterm infants at 1-month post discharge.
Preterm infants were recruited from the Wellington regional neonatal intensive care unit (NICU) and 24-h pulse oximetry recordings performed immediately before discharge. Infants born <32 weeks gestational age (GA) had repeat oximetry 1-month post discharge. Oxygenation measures included the 3% and 4% desaturation (DSI 3%, DSI 4%) indices.
At discharge from the neonatal unit the median and interquartile range (IQR) for DSI 4% was 51 (31-74) events per hour with normal mean SpO (median of 97.9% [97.2-98.8 IQR]). Episodes of IH 1 month post discharge decreased with improvements of between 42% and 57% seen for the three DSI measures. Infants <32 weeks GA had higher median DSI 3 and 4% values at discharge but differences when compared with late preterm infants were not significant.
Preterm infants have frequent episodes of IH as measured by the 3% and 4% DSI when deemed otherwise ready for discharge home. Further research in a larger cohort of very preterm infants and also in term infants is needed to determine the significance of this finding.
本研究旨在：(i)通过脉搏血氧饱和度监测仪记录的氧减饱和指数（DSI），确定新生儿出院时早产儿间歇性低氧血症（IH）的患病率；(ii)确定出院后 1 个月极早产儿的数值变化。
从惠灵顿地区新生儿重症监护病房（NICU）招募早产儿，并在出院前进行 24 小时脉搏血氧仪记录。出生时胎龄<32 周的婴儿在出院后 1 个月重复进行血氧仪检查。氧合测量指标包括 3%和 4%的低氧饱和度（DSI 3%、DSI 4%）。
在新生儿病房出院时，DSI 4%的中位数和四分位距（IQR）为 51（31-74）事件/小时，平均 SpO 正常（中位数为 97.9%[97.2-98.8 IQR]）。出院后 1 个月 IH 发作减少，三种 DSI 测量值均改善了 42%至 57%。胎龄<32 周的婴儿在出院时的 DSI 3 和 4%的中位数值较高，但与晚期早产儿相比，差异无统计学意义。
早产儿在出院时，即使被认为可以出院回家，通过 DSI 3%和 4%也会出现频繁的 IH 发作。需要在更大的极早产儿队列和足月婴儿中进行进一步研究，以确定这一发现的意义。
