a Department of Psychology , Sofia University , Palo Alto , CA , USA.
b College Street Women's Centre for Health Education & Counselling , Toronto Ontario , Canada.
J Psychoactive Drugs. 2019 Apr-Jun;51(2):118-122. doi: 10.1080/02791072.2019.1593561. Epub 2019 Mar 29.
Albert Hoffman suggested that low doses of LSD might be an appropriate alternative to Ritalin. Following this possibility, a systematic exploration of the effects of "microdoses," comprising hundreds of lengthy descriptive reports, was undertaken. Based on these reports, using a psychedelic in the microdose range (10 micrograms) every three days was determined to be safe across a wide variety of individuals and conditions. Over 18 months, more than a thousand individuals from 59 countries did a daily evaluation of negative and positive emotional state using the PANAS checklist plus written reports for between one week and four months. Participant reports suggested that spaced but repeated microdoses were followed by improvements in negative moods, especially depression, and increases in positive moods. Increased energy, improved work effectiveness, and improved health habits were observed in clinical and non-clinical populations. Smaller samples described alleviation of symptoms in migraine headaches, pre-menstrual syndromes, traumatic brain injury, shingles, and other conditions not previously associated with psychedelic use.
阿尔伯特·霍夫曼（Albert Hoffman）曾提出，低剂量的 LSD 可能是利他林（Ritalin）的合适替代品。鉴于这种可能性，人们对“微剂量”的影响进行了系统的探索，共收到了数百份详尽的描述性报告。基于这些报告，人们确定在广泛的个体和条件下，每三天使用一次微剂量范围（10 微克）的迷幻剂是安全的。在 18 个月的时间里，来自 59 个国家的 1000 多名参与者使用 PANAS 检查表和书面报告，对负面和正面情绪状态进行了每日评估，时间从一周到四个月不等。参与者的报告表明，间隔但重复的微剂量后，负面情绪，尤其是抑郁情绪得到改善，积极情绪增加。在临床和非临床人群中观察到精力增加、工作效率提高和健康习惯改善。较小的样本描述了偏头痛、经前综合征、创伤性脑损伤、带状疱疹以及其他以前与迷幻剂使用无关的疾病症状的缓解。
