Psychiatry, University of Toronto Faculty of Medicine, Toronto, Canada.
Psychology, University of Toronto, Toronto, Canada.
J Psychopharmacol. 2020 Jun;34(6):612-622. doi: 10.1177/0269881120908004. Epub 2020 Feb 28.
Microdosing psychedelics - the practice of consuming small, sub-hallucinogenic doses of substances such as LSD or psilocybin - is gaining attention in popular media but remains poorly characterized. Contemporary studies of psychedelic microdosing have yet to report the basic psychiatric descriptors of psychedelic microdosers.
To examine the practices and demographics of a population of psychedelic microdosers - including their psychiatric diagnoses, prescription medications, and recreational substance use patterns - to develop a foundation on which to conduct future clinical research.
Participants ( = 909; M = 26.9, SD = 8.6; male = 83.2%; White/European = 79.1%) recruited primarily from the online forum Reddit completed an anonymous online survey. Respondents who reported using LSD, psilocybin, or both for microdosing were grouped and compared with non-microdosing respondents using exploratory odds ratio testing on demographic variables, rates of psychiatric diagnoses, and past-year recreational substance use.
Of microdosers, most reported using LSD (59.3%; M = 13 mcg, or 11.3% of one tab) or psilocybin (25.9%; M = 0.3 g of dried psilocybin mushrooms) on a one-day-on, two-days-off schedule. Compared with non-microdosers, microdosers were significantly less likely to report a history of substance use disorders (SUDs; OR = 0.17 (95% CI: 0.05-0.56)) or anxiety disorders (OR = 0.61 (95% CI: 0.41-0.91)). Microdosers were also more likely to report recent recreational substance use compared with non-microdosers (OR 5.2 (95% CI: 2.7-10.8)).
Well-designed randomized controlled trials are needed to evaluate the safety and tolerability of this practice in clinical populations and to test claims about potential benefits.
微剂量摄入迷幻剂——即摄入少量、低致幻剂量的致幻剂，如 LSD 或裸盖菇素——在大众媒体中受到关注，但仍缺乏特征描述。当代迷幻剂微剂量研究尚未报告迷幻剂微剂量使用者的基本精神科描述。
研究迷幻剂微剂量使用者的行为和人口统计学特征，包括他们的精神诊断、处方药物和娱乐性物质使用模式，为未来的临床研究奠定基础。
参与者（n=909；M=26.9，SD=8.6；男性=83.2%；白种人/欧洲人=79.1%）主要从在线论坛 Reddit 招募，完成了一项匿名在线调查。报告使用 LSD、裸盖菇素或两者进行微剂量的受访者被分为一组，并与非微剂量受访者进行比较，使用探索性比值比检验人口统计学变量、精神诊断率和过去一年的娱乐性物质使用情况。
在微剂量使用者中，大多数人报告说使用 LSD（59.3%；M=13mcg，或一片的 11.3%）或裸盖菇素（25.9%；M=0.3g 干裸盖菇素蘑菇），采用一天使用、两天停用的时间表。与非微剂量使用者相比，微剂量使用者报告有物质使用障碍（SUD）史的可能性显著降低（OR=0.17（95%CI：0.05-0.56））或焦虑障碍（OR=0.61（95%CI：0.41-0.91））。微剂量使用者最近也更有可能报告娱乐性物质使用情况，与非微剂量使用者相比（OR=5.2（95%CI：2.7-10.8））。
需要进行精心设计的随机对照试验，以评估这种做法在临床人群中的安全性和耐受性，并验证潜在益处的说法。
