Dehlin O
Acta Psychiatr Scand Suppl. 1986;329:112-5. doi: 10.1111/j.1600-0447.1986.tb10545.x.
The hypnotic effect of chlormethiazole was studied for 3 months in 20 geriatric in-patients. Registered variables were the percentage of patients asleep at 10 pm and 6 am and the observed number of awakenings. Mental and somatic variables were rated according to the Crichton Geriatric Behavioural Rating Scale. Observations were made every second week. In 11 of the patients the plasma concentration of chlormethiazole was measured at regular intervals. No systematic significant change with time was observed for the percentage of patients asleep at 10 pm or for the number of awakenings. A significant decrease occurred in the percentage of patients asleep at 6 am. The long-term treatment with chlormethiazole did not cause any deterioration in the patients' behaviour, according to the geriatric rating scheme. Observed peak plasma levels of chlormethiazole did not change significantly during the study. Great interindividual variations in the plasma concentrations were observed. The results indicate that chlormethiazole is lastingly effective as a hypnotic agent in geriatric patients.
对20名老年住院患者使用氯美噻唑的催眠效果进行了为期3个月的研究。记录的变量包括晚上10点和早上6点入睡患者的百分比以及观察到的觉醒次数。根据克里顿老年行为评定量表对精神和躯体变量进行评分。每两周进行一次观察。对11名患者定期测量氯美噻唑的血浆浓度。晚上10点入睡患者的百分比或觉醒次数未观察到随时间的系统性显著变化。早上6点入睡患者的百分比出现显著下降。根据老年评定方案，氯美噻唑的长期治疗未导致患者行为出现任何恶化。研究期间观察到的氯美噻唑血浆峰值水平无显著变化。观察到血浆浓度存在很大的个体差异。结果表明，氯美噻唑作为催眠剂对老年患者具有持久疗效。
