Van Mieghem W, De Backer G, De Wispelaere B, Billiet L, Cosemans J
Acta Cardiol. 1978;33(4):253-62.
Continuous phentolamine infusion, produced a marked decrease in pulmonary arterial pressure and pulmonary vascular resistance with an increase in cardiac output, in the majority of a group of 13 patients with chronic obstructive pulmonary disease and cor pulmonale. Changes in vital capacity, forced expiratory volume in one second, arterial blood gas values and peripheral blood pressure were not significant except in one patient. The changes in the pulmonary circulation are probably due to the alpha blocking effect of phentolamine, although a direct effect of the drug on vascular smooth muscle can not be excluded.
在一组13例慢性阻塞性肺疾病合并肺心病患者中，大多数患者持续输注酚妥拉明后，肺动脉压和肺血管阻力显著降低，心输出量增加。除1例患者外，肺活量、一秒用力呼气量、动脉血气值和外周血压的变化不显著。肺循环的变化可能是由于酚妥拉明的α受体阻滞作用，尽管不能排除该药物对血管平滑肌的直接作用。
