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以玉米醇溶蛋白/阿拉伯胶纳米粒子为稳定剂的Pickering 乳液,其中百里香酚作为一种抗菌药物递送系统。

Zein/gum Arabic nanoparticle-stabilized Pickering emulsion with thymol as an antibacterial delivery system.

机构信息

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, China; National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi, Jiangsu, 214122, China; Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, Jiangnan University, Wuxi, Jiangsu, 214122, China.

National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi, Jiangsu, 214122, China.

出版信息

Carbohydr Polym. 2018 Nov 15;200:416-426. doi: 10.1016/j.carbpol.2018.08.025. Epub 2018 Aug 9.

DOI:10.1016/j.carbpol.2018.08.025
PMID:30177182
Abstract

Zein/gum Arabic (GA) nanoparticles (ZGPs) were fabricated to stabilize the oil-water interface of a Pickering emulsion. The Pickering emulsion was successfully fabricated at an oil fraction of 0.3 with 6.25% concentration of ZGPs. The droplet size and creaming index of the Pickering emulsions were influenced significantly by the concentrations of the ZGPs and oil fractions. Morphological observations showed that droplet aggregation occurred when the concentrations of ZGPs decreased or the oil fraction increased. The interfacial tension and rheological properties of the Pickering emulsions indicated that the ZGPs formed a stable oil-water interfacial layer and limited agglomeration and Ostwald ripening. Thymol loaded ZGP-stabilized Pickering emulsion was able to significantly inhibit the growth of E. coli. In addition, the ZGP-stabilized Pickering emulsion with thymol exhibited a controlled-release effect of thymol and antibacterial activity due to the protective effect of the stable interfacial layer of the ZPGs.

摘要

Zein/阿拉伯胶(GA)纳米颗粒(ZGPs)被制备用来稳定 Pickering 乳液的油水界面。在油分数为 0.3 时,成功地制备了 Pickering 乳液,ZGPs 的浓度为 6.25%。Pickering 乳液的液滴尺寸和增稠指数受 ZGPs 和油分数浓度的显著影响。形态观察表明,当 ZGPs 浓度降低或油分数增加时,液滴发生聚集。界面张力和流变性能表明,ZGPs 形成了一个稳定的油水界面层,限制了聚集和奥斯特瓦尔德熟化。负载百里香酚的 ZGP 稳定的 Pickering 乳液能够显著抑制大肠杆菌的生长。此外,由于 ZPGs 稳定的界面层的保护作用,负载百里香酚的 ZGP 稳定的 Pickering 乳液具有百里香酚的控制释放效果和抗菌活性。

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