Department of Neurosurgery, Sarawak General Hospital, Ministry of Health, Jalan Hospital, Kuching, Malaysia.
Department of Neurosurgery, Sarawak General Hospital, Ministry of Health, Jalan Hospital, Kuching, Malaysia.
World Neurosurg. 2019 Jul;127:e497-e502. doi: 10.1016/j.wneu.2019.03.183. Epub 2019 Mar 26.
BACKGROUND: Replacing the skull defect with synthetic materials for hyperostotic bone secondary to meningioma is recommended owing to the possibility of tumor invasion. In our institution, neurosurgeons have been putting back the refashioned hyperostotic bone flap after meningioma excision because of budget constraints. The aim of this study was to review the long-term meningioma recurrence rate in these patients. METHODS: This was a nonrandomized, prospective observational study conducted from September 2011 to January 2015 on patients with intracranial convexity and parasagittal meningiomas. Preoperative computed tomography brain scans were obtained in all patients to confirm bony hyperostosis. Intraoperatively, part of the hyperostotic bone was sent for histopathologic examination. The rest of the bone flap was refashioned by drilling off the hyperostotic part. The bone flap was put back over the craniotomy site after soaking in distilled water. All patients were followed up for tumor recurrence. RESULTS: The study included 34 patients with convexity or parasagittal meningioma World Health Organization grade I-II who underwent Simpson grade Ia and IIa excision. Median follow-up was 63.5 months (mean 64.9 ± 9.4 months). The hyperostotic bone flap showed presence of tumor in 35% of patients. There were 2 patients with parasagittal meningiomas after Simpson grade IIa resections who developed tumor recurrences. CONCLUSIONS: Our study found that meningioma recurrence was unlikely when autologous cranioplasty was done with refashioned hyperostotic bone. This could be done in the same setting with meningioma excision. There was no recurrence in convexity meningiomas at mean 5-year follow-up.
背景:由于存在肿瘤侵袭的可能性,建议用合成材料替代因脑膜瘤导致的骨质过度增生的颅骨缺损。由于预算限制,我院神经外科医生在切除脑膜瘤后会将整形后的骨质瓣放回原处。本研究旨在回顾这些患者的脑膜瘤长期复发率。
方法:这是一项从 2011 年 9 月至 2015 年 1 月进行的非随机、前瞻性观察研究,纳入对象为颅内凸面和矢状旁脑膜瘤患者。所有患者均行术前颅脑 CT 扫描以确认骨质过度增生。术中部分骨质过度增生的部分送组织病理学检查,其余骨质用钻孔去除过度增生的部分进行整形。将骨质瓣浸泡在蒸馏水中后放回颅骨切开部位。所有患者均随访肿瘤复发情况。
结果:研究纳入了 34 例接受 World Health Organization 分级 I-II 级 Simpson 分级 Ia 和 IIa 切除的凸面或矢状旁脑膜瘤患者。中位随访时间为 63.5 个月(平均 64.9 ± 9.4 个月)。骨质瓣显示有肿瘤存在于 35%的患者中。2 例接受 Simpson 分级 IIa 切除的矢状旁脑膜瘤患者出现肿瘤复发。
结论:我们的研究发现,用整形后的骨质进行自体颅骨修复时,脑膜瘤复发的可能性较小。可以在切除脑膜瘤的同一情况下进行。在平均 5 年的随访中,凸面脑膜瘤无复发。
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