Chen William C, Lucas Calixto-Hope G, Magill Stephen T, Rogers C Leland, Raleigh David R
Department of Radiation Oncology, University of California San Francisco, San Francisco, CA 94143, USA.
Department of Pathology, University of California San Francisco, San Francisco, CA 94143, USA.
Neurooncol Adv. 2023 Jun 3;5(Suppl 1):i67-i83. doi: 10.1093/noajnl/vdac088. eCollection 2023 May.
Meningiomas comprise a histologically and clinically diverse set of tumors arising from the meningothelial lining of the central nervous system. In the past decade, remarkable progress has been made in deciphering the biology of these common neoplasms. Nevertheless, effective systemic or molecular therapies for meningiomas remain elusive and are active areas of preclinical and clinical investigation. Thus, standard treatment modalities for meningiomas are limited to maximal safe resection, radiotherapy, or radiosurgery. This review examines the history, clinical rationale, and future directions of radiotherapy and radiosurgery as integral and effective treatments for meningiomas.
脑膜瘤是一组组织学和临床特征各异的肿瘤，起源于中枢神经系统的脑膜内皮细胞。在过去十年中，在解读这些常见肿瘤的生物学特性方面取得了显著进展。然而，针对脑膜瘤的有效全身治疗或分子治疗仍然难以实现，仍是临床前和临床研究的活跃领域。因此，脑膜瘤的标准治疗方式仅限于最大程度的安全切除、放射治疗或放射外科手术。本综述探讨了放射治疗和放射外科手术作为脑膜瘤整体有效治疗方法的历史、临床依据及未来方向。
