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Impact of 9q deletions on the classification of patients with acute myeloid leukemia.

作者信息

Balk Bettina, Haferlach Torsten, Meggendorfer Manja, Kern Wolfgang, Haferlach Claudia, Stengel Anna

机构信息

MLL Munich Leukemia Laboratory, Max-Lebsche-Platz 31, 81377, Munich, Germany.

出版信息

J Cancer Res Clin Oncol. 2019 Nov;145(11):2871-2874. doi: 10.1007/s00432-019-02908-0. Epub 2019 Mar 29.

DOI:10.1007/s00432-019-02908-0
PMID:30927073
Abstract
摘要

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Impact of 9q deletions on the classification of patients with acute myeloid leukemia.9号染色体长臂缺失对急性髓系白血病患者分类的影响。
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2
Acute myeloid leukemia with del(9q) is characterized by frequent mutations of NPM1, DNMT3A, WT1 and low expression of TLE4.伴有9号染色体长臂缺失（del(9q)）的急性髓系白血病的特征是NPM1、DNMT3A、WT1频繁发生突变以及TLE4表达降低。
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Genomic Features of Interstitial Deletions of Chromosome 9q in Acute Myeloid Leukemia.

本文引用的文献

1
Characterization of acute myeloid leukemia with del(9q) - Impact of the genes in the minimally deleted region.伴有9号染色体长臂缺失（del(9q)）的急性髓系白血病的特征——最小缺失区域内基因的影响
Leuk Res. 2019 Jan;76:15-23. doi: 10.1016/j.leukres.2018.11.007. Epub 2018 Nov 17.
2
Acute myeloid leukemia with del(9q) is characterized by frequent mutations of NPM1, DNMT3A, WT1 and low expression of TLE4.伴有9号染色体长臂缺失（del(9q)）的急性髓系白血病的特征是NPM1、DNMT3A、WT1频繁发生突变以及TLE4表达降低。
Genes Chromosomes Cancer. 2017 Jan;56(1):75-86. doi: 10.1002/gcc.22418. Epub 2016 Oct 25.
3
The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia.
急性髓系白血病中 9q 染色体臂间缺失的基因组特征。
Cytogenet Genome Res. 2022;162(3):119-123. doi: 10.1159/000525010. Epub 2022 Jun 8.
2016 年版世界卫生组织髓系肿瘤和急性白血病分类。
Blood. 2016 May 19;127(20):2391-405. doi: 10.1182/blood-2016-03-643544. Epub 2016 Apr 11.
4
Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance.年轻成人急性髓系白血病的分子图谱及其临床相关性。
Blood. 2016 Jan 7;127(1):29-41. doi: 10.1182/blood-2015-07-604496. Epub 2015 Dec 10.
5
Acute myeloid leukemia ontogeny is defined by distinct somatic mutations.急性髓系白血病的发生是由独特的体细胞突变所定义的。
Blood. 2015 Feb 26;125(9):1367-76. doi: 10.1182/blood-2014-11-610543. Epub 2014 Dec 30.
6
Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials.在英国医学研究理事会试验中治疗的 5876 例年轻成年患者中，对罕见重现染色体异常进行细胞遗传学分类的细化：确定其预后意义。
Blood. 2010 Jul 22;116(3):354-65. doi: 10.1182/blood-2009-11-254441. Epub 2010 Apr 12.
7
Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel, on behalf of the European LeukemiaNet.成人急性髓系白血病的诊断和治疗：代表欧洲白血病网的国际专家小组的建议。
Blood. 2010 Jan 21;115(3):453-74. doi: 10.1182/blood-2009-07-235358. Epub 2009 Oct 30.
8
Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival.急性髓系白血病（AML）中常见缺失区域del(9q)的TLE1和TLE4缺失与AML1-ETO协同作用，影响髓系细胞增殖和存活。
Blood. 2008 Apr 15;111(8):4338-47. doi: 10.1182/blood-2007-07-103291. Epub 2008 Feb 7.
9
Acute myeloid leukemia with deletion 9q within a noncomplex karyotype is associated with CEBPA loss-of-function mutations.非复杂核型中伴有9号染色体长臂缺失的急性髓系白血病与CEBPA功能丧失性突变相关。
Genes Chromosomes Cancer. 2005 Apr;42(4):427-32. doi: 10.1002/gcc.20152.
10
Comparison of chromosome banding analysis, interphase- and hypermetaphase-FISH, qualitative and quantitative PCR for diagnosis and for follow-up in chronic myeloid leukemia: a study on 350 cases.染色体显带分析、间期和超中期荧光原位杂交、定性和定量聚合酶链反应在慢性髓性白血病诊断及随访中的比较：一项350例患者的研究
Leukemia. 2002 Jan;16(1):53-9. doi: 10.1038/sj.leu.2402329.