Tager I B, Weiss S T, Muñoz A, Welty C, Speizer F E
Am Rev Respir Dis. 1986 Sep;134(3):502-8. doi: 10.1164/arrd.1986.134.3.502.
A population-based, epidemiologic investigation conducted in children, adolescents, and young adults analyzed the response to eucapneic hyperventilation with cold air as a continuous variable to better define factors that influence the expression of bronchial responsiveness. Among respiratory illness/symptom variables, only the report of asthma or persistent wheeze in the previous year and the report of a respiratory illness that led to activity restriction were significantly associated with response to cold air. Furthermore, a low, prechallenge FEF/FVC ratio was a significant predictor of response, especially among those subjects who reported a respiratory illness that led to activity restriction. This relationship was not observed for a low prechallenge FEF.
一项针对儿童、青少年和青年人群的基于人群的流行病学调查，将冷空气诱发的等碳酸血症性过度通气反应作为连续变量进行分析，以更好地确定影响支气管反应性表达的因素。在呼吸系统疾病/症状变量中，仅前一年的哮喘或持续性喘息报告以及导致活动受限的呼吸系统疾病报告与冷空气反应显著相关。此外，激发前FEF/FVC比值较低是反应的显著预测指标，尤其是在那些报告有导致活动受限的呼吸系统疾病的受试者中。对于激发前FEF较低的情况，未观察到这种关系。
