两种来自 poporum 的新氮杂石房蛤毒素，以及 Amphidomataceae（甲藻）产生的氮杂石房蛤毒素的综合汇编。
Two novel azaspiracids from Azadinium poporum, and a comprehensive compilation of azaspiracids produced by Amphidomataceae, (Dinophyceae).
机构信息
Alfred Wegener Institut-Helmholtz Zentrum für Polar- und Meeresforschung, Am Handelshafen 12, 27570 Bremerhaven, Germany.
Alfred Wegener Institut-Helmholtz Zentrum für Polar- und Meeresforschung, Am Handelshafen 12, 27570 Bremerhaven, Germany.
出版信息
Harmful Algae. 2019 Feb;82:1-8. doi: 10.1016/j.hal.2018.12.005. Epub 2018 Dec 27.
Two novel azaspiracids (AZA) with a molecular mass of 869 Da were found in Pacific strains of Azadinium poporum and characterized by tandem mass spectrometry and high resolution mass spectrometry (HRMS). One compound, AZA-42, was found in Az. poporum strains AZFC25 and AZFC26, both isolated from the South China Sea. AZA-42 belongs to the 360-type AZA that in comparison to AZA-1 has an additional double bond in the F-I ring system of AZA comprising C28-C40. The other compound, AZA-62, was detected in Az. poporum strain 1D5 isolated off Chañaral, Northern Chile. Mass spectral data indicate that AZA-62 is a variant of AZA-11 with an additional double bond in the C1-C9 region of AZA. In addition to the description of the two novel AZA, a comprehensive list of all AZA known to be produced by species of the genera Azadinium and Amphidoma comprising 26 AZA variants is presented.
两种新型azaspiracid（AZA），分子量为 869Da，在太平洋 Azadinium poporum 菌株中被发现，并通过串联质谱和高分辨率质谱（HRMS）进行了表征。一种化合物 AZA-42 存在于从南海分离出的 Az. poporum 菌株 AZFC25 和 AZFC26 中。AZA-42 属于 360 型 AZA，与 AZA-1 相比，在 AZA 的 F-I 环系统中增加了一个双键，由 C28-C40 组成。另一种化合物 AZA-62 存在于从智利北部查尼亚拉尔分离出的 Az. poporum 菌株 1D5 中。质谱数据表明，AZA-62 是 AZA-11 的变体，在 AZA 的 C1-C9 区域增加了一个双键。除了描述这两种新型 AZA 外，还列出了所有由 Azadinium 和 Amphidoma 属的物种产生的已知 AZA 的综合清单，包括 26 种 AZA 变体。
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