脂多糖刺激的小鼠脾细胞培养上清液中白细胞介素3样活性的存在。
Presence of interleukin 3-like activity in the supernatants of lipopolysaccharide-stimulated mouse splenocytes.
作者信息
Cavaillon J M, Fitting C, David B
出版信息
Biochem Biophys Res Commun. 1986 Aug 14;138(3):1322-7. doi: 10.1016/s0006-291x(86)80427-2.
PMID:3092823
Abstract
An Interleukin 3 (IL 3) activity was found in the supernatants of mouse spleen cells stimulated by lipopolysaccharide (LPS). The IL 3 activity was maximum in the supernatants of 5 to 7 days cultures. IL 3 activity was assessed by the capacity of the spleen cell supernatants to allow the growth of the FDC-P2 cell line, a strictly IL 3 dependent cell line. Polymyxin B could inhibit the IL 3 induction by LPS.
摘要
在脂多糖（LPS）刺激的小鼠脾细胞上清液中发现了白细胞介素3（IL-3）活性。IL-3活性在培养5至7天的上清液中最高。通过脾细胞上清液支持FDC-P2细胞系生长的能力来评估IL-3活性，FDC-P2是一种严格依赖IL-3的细胞系。多粘菌素B可抑制LPS诱导的IL-3产生。
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