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随机对照试验表明,包载布比卡因的脂质体减少了肩袖修复术后阿片类药物的消耗。

Liposomal bupivacaine reduces opiate consumption after rotator cuff repair in a randomized controlled trial.

机构信息

Orthopaedic & Neurosurgery Specialists, Greenwich, CT, USA; The ONS Foundation for Clinical Research and Education, Greenwich, CT, USA.

The ONS Foundation for Clinical Research and Education, Greenwich, CT, USA.

出版信息

J Shoulder Elbow Surg. 2019 May;28(5):819-827. doi: 10.1016/j.jse.2019.01.008. Epub 2019 Mar 28.

Abstract

BACKGROUND

Arthroscopic rotator cuff repair (ARCR) provides excellent clinical outcomes but is often associated with significant postoperative pain. The use of intraoperative anesthesia in conjunction with multimodal pharmacologic strategies is a widely accepted approach for managing surgical pain and reducing opiate use. The purpose of this study was to determine whether using a combined field and suprascapular nerve block with liposomal bupivacaine (LB) in addition to an interscalene block would provide greater pain relief and a reduction in opiate consumption compared with an interscalene block alone.

METHODS

The study enrolled 50 patients with full-thickness rotator cuff tears undergoing primary ARCR surgery. Patients were randomized to receive intraoperative LB (n = 25) or not (n = 25) and given postoperative "pain journals" to document visual analog scale pain scores and to track their daily opioid consumption during the first 5 postoperative days.

RESULTS

Patients in the LB group reported statistically and clinically lower pain scores during postoperative days 1 and 2 (P < .0001 and P = .03, respectively). In addition, patients in the LB group consumed significantly fewer narcotics than the control group during the 5-day period, demonstrating a 64% reduction in total narcotic consumption (P = .002).

CONCLUSION

The findings of this study suggest that the addition of LB to multimodal anesthetic protocols significantly reduces the acute perioperative pain experienced following rotator cuff repair and the number of narcotic pills consumed in the first 5 days after ARCR. Furthermore, the findings provide guidelines for postoperative narcotic prescribing to reduce the quantity of opiates prescribed.

摘要

背景

关节镜下肩袖修复术(ARCR)可提供出色的临床效果,但通常与明显的术后疼痛相关。术中麻醉与多模式药物策略联合使用是一种广泛接受的方法,可用于管理手术疼痛和减少阿片类药物的使用。本研究旨在确定与单独使用肌间沟阻滞相比,在使用肌间沟阻滞的同时使用脂质体布比卡因(LB)进行肩胛上神经和肩胛下神经联合阻滞是否能提供更大的疼痛缓解和减少阿片类药物的消耗。

方法

该研究纳入了 50 例接受初次 ARCR 手术的全层肩袖撕裂患者。患者随机分为接受术中 LB 组(n = 25)或不接受 LB 组(n = 25),并在术后给予“疼痛日记”,以记录视觉模拟评分(VAS)疼痛评分,并跟踪他们在术后第 5 天的每日阿片类药物消耗。

结果

LB 组患者在术后第 1 天和第 2 天报告的疼痛评分明显较低(P <.0001 和 P =.03)。此外,LB 组患者在 5 天期间消耗的阿片类药物明显少于对照组,总阿片类药物消耗量减少了 64%(P =.002)。

结论

本研究的结果表明,LB 联合多模式麻醉方案可显著减轻肩袖修复术后的急性围手术期疼痛,并减少 ARCR 术后第 5 天内消耗的阿片类药物数量。此外,研究结果为术后阿片类药物处方提供了指导,以减少阿片类药物的处方数量。

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