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阿片类药物风险工具:这个经过验证的工具能否预测关节镜下肩袖修复术后的阿片类药物依赖情况?

The Opioid Risk Tool: Can This Validated Tool Predict Post-Operative Opioid Dependence Following Arthroscopic Rotator Cuff Repair?

作者信息

DeBernardis Dennis A, Stenson DeBernardis, Cheeseman Quincy T, Austin Luke S

机构信息

Rowan University School of Osteopathic Medicine, Department of Orthopedic Surgery, Stratford, NJ, USA.

The Rothman Institute at Jefferson University, Philadelphia, PA, USA.

出版信息

Arch Bone Jt Surg. 2022 Jan;10(1):98-103. doi: 10.22038/ABJS.2021.55165.2746.

Abstract

BACKGROUND

Numerous attempts have been made to decrease the incidence of opioid dependence after orthopedic surgeries. However, no effective means of preoperative risk stratification currently exists. The purpose of this study was to determine the ability of the Opioid Risk Tool (ORT) to predict the rate of opioid dependence 2 years after arthroscopic rotator cuff repair (ARCR).

METHODS

We prospectively evaluated all patients undergoing primary ARCR at a single institution over a 1.5 year period with a minimum of 2-year follow-up. All patients completed the ORT prior to surgery and were stratified into Low, Moderate, and High risk categories. The primary outcome was postoperative opioid dependence, defined as receiving a minimum of 6 opioid prescriptions within 2 years following surgery. Secondary outcomes included the total number of morphine milligram equivalents prescribed, total number of opioid prescriptions filled, and total number of opioid pills prescribed during this time interval. All outcome variables were compared amongst Low, Moderate, and High risk groups. Assessment of a statistical correlation between each outcome variable and individual numerical ORT scores (1-9) was performed.

RESULTS

A total of 137 patients were included for analysis. No statistically significant difference was noted in any primary or secondary outcome variable when compared between Low, Moderate, and High risk groups. The total cohort demonstrated a 19% rate of post-operative opioid dependence. No correlation was identified between any outcome variable and individual numerical ORT scores. A greater rate of dependence and quantity of opioids prescribed was noted amongst patients with a history of prior opioid use.

CONCLUSION

The ORT was not predictive of the risk of opioid dependence or quantity of opioids prescribed after ARCR. Attention should be focused on alternative means of identification and management of patients at risk for opioid dependence after orthopedic procedures, including those with a history of prior opioid use.

摘要

背景

人们已多次尝试降低骨科手术后阿片类药物依赖的发生率。然而,目前尚无有效的术前风险分层方法。本研究的目的是确定阿片类药物风险工具(ORT)预测关节镜下肩袖修复术(ARCR)后2年阿片类药物依赖率的能力。

方法

我们对一家机构1.5年内接受初次ARCR手术且随访至少2年的所有患者进行了前瞻性评估。所有患者在手术前完成ORT评估,并被分为低、中、高风险类别。主要结局是术后阿片类药物依赖,定义为术后2年内至少接受6张阿片类药物处方。次要结局包括在此时间间隔内开具的吗啡毫克当量总数、填写的阿片类药物处方总数以及开具的阿片类药物药丸总数。所有结局变量在低、中、高风险组之间进行比较。对每个结局变量与ORT个体数值评分(1 - 9)之间的统计相关性进行了评估。

结果

共纳入137例患者进行分析。低、中、高风险组之间在任何主要或次要结局变量上均未发现统计学显著差异。整个队列的术后阿片类药物依赖率为19%。未发现任何结局变量与ORT个体数值评分之间存在相关性。有阿片类药物使用史的患者中,依赖率和开具的阿片类药物数量更高。

结论

ORT不能预测ARCR术后阿片类药物依赖风险或开具的阿片类药物数量。应关注骨科手术后有阿片类药物依赖风险患者的其他识别和管理方法,包括有阿片类药物使用史的患者。

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