Anxiety Disorders Center, Institute of Living/Hartford Hospital, 200 Retreat Avenue, Hartford, CT, 06106, USA.
Olin Neuropsychiatry Research Center, Institute of Living/Hartford Hospital, 400 Washington Street, Hartford, CT, 06106, USA; Department of Psychiatry, Yale University School of Medicine, 300 George Street, New Haven, CT, 06511, USA.
J Psychiatr Res. 2019 Jun;113:108-116. doi: 10.1016/j.jpsychires.2019.03.022. Epub 2019 Mar 26.
Emerging research suggests that hoarding disorder (HD) is associated with abnormal hemodynamic activity in frontal brain regions. Prior studies have not examined intrinsic network connectivity in HD during unstructured "resting state" fMRI. Furthermore, it remains unclear whether previously observed HD abnormalities might be better explained by the presence of other disorders frequently comorbid with HD, such as major depressive disorder (MDD). The current study compared resting state functional connectivity in HD-only patients (n = 17), MDD-only patients (n = 8), patients with co-occurring HD and MDD (n = 10), and healthy control participants (n = 18). Using independent component analysis, we found that HD-only patients exhibited lower functional connectivity in a "task positive" cognitive control network, compared to the other three groups. The HD group also had greater connectivity in regions of the "task negative" default mode network than did the other groups. Findings suggest that HD is associated with a unique neurobiological profile, and are discussed in terms of recent neurological and neuropsychological findings and models in HD and related disorders.
新兴研究表明，囤积症（HD）与额叶大脑区域的异常血液动力学活动有关。先前的研究并未在无结构的“静息状态” fMRI 中检查 HD 期间的内在网络连通性。此外，尚不清楚先前观察到的 HD 异常是否可以通过与 HD 频繁共病的其他疾病（例如重度抑郁症（MDD））的存在来更好地解释。本研究比较了仅 HD 患者（n=17），仅 MDD 患者（n=8），同时患有 HD 和 MDD 的患者（n=10）和健康对照组参与者（n=18）的静息状态功能连通性。使用独立成分分析，我们发现与其他三组相比，仅 HD 患者的“任务积极”认知控制网络的功能连通性较低。与其他组相比，HD 组在“任务消极”默认模式网络的区域中具有更高的连通性。研究结果表明，HD 与独特的神经生物学特征有关，并根据 HD 和相关疾病的最新神经学和神经心理学发现和模型进行了讨论。
