Chapman University, Department of Psychology, One University Drive, Orange, CA, 92866, USA; A.T. Still University, School of Osteopathic Medicine, 5850 East Still Circle, Mesa, AZ, 85206, USA.
University at Buffalo, Department of Psychology, Park Hall 206, Buffalo, NY, 14260, USA.
Biol Psychol. 2019 Oct;147:107686. doi: 10.1016/j.biopsycho.2019.03.015. Epub 2019 Mar 27.
Postpartum depression (PPD) is a debilitating mental illness affecting approximately 13% of mothers after birth. Both genetic and psychosocial factors contribute to PPD risk, but very little is known about how these factors interact. We tested whether the rs53576 polymorphism in the oxytocin receptor (OXTR) gene accounts for variation in the impact of low social support as a risk factor for depression among mothers during the perinatal period. New mothers (N = 220) provided saliva or blood DNA samples and completed surveys assessing PPD symptoms and perceived social support. In a significant interaction, social support from the baby's father predicted PPD symptoms to a greater extent among mothers with the GG compared to AG and AA genotypes. These results add to converging evidence that variation in OXTR rs53576 moderates the impact of the social environment on PPD.
产后抑郁症（PPD）是一种使人虚弱的精神疾病，大约有 13%的产妇在产后会受到影响。遗传和社会心理因素都会增加 PPD 的患病风险，但对于这些因素如何相互作用，我们知之甚少。我们检测了催产素受体（OXTR）基因中的 rs53576 多态性是否可以解释低社会支持作为围产期母亲抑郁风险因素的影响程度的变化。新妈妈（N=220）提供了唾液或血液 DNA 样本，并完成了评估 PPD 症状和感知社会支持的调查。在一个显著的相互作用中，与 AG 和 AA 基因型的母亲相比，来自婴儿父亲的社会支持在 GG 基因型的母亲中对 PPD 症状的预测作用更大。这些结果增加了越来越多的证据，即 OXTR rs53576 的变异可以调节社会环境对 PPD 的影响。
