健康久坐的中年成年人中 DHEAS、睾酮和皮质醇与 S-Klotho 血浆水平的相关性研究。
Study of the association of DHEAS, testosterone and cortisol with S-Klotho plasma levels in healthy sedentary middle-aged adults.
机构信息
Department of Medical Physiology, School of Medicine, University of Granada, 18016 Granada, Spain.
Department of Medical Physiology, School of Medicine, University of Granada, 18016 Granada, Spain.
出版信息
Exp Gerontol. 2019 Jul 1;121:55-61. doi: 10.1016/j.exger.2019.03.010. Epub 2019 Mar 27.
BACKGROUND
α-Klotho is a recently discovered gene that accelerates ageing when disrupted and extends lifespan when overexpressed. The age-related decline in DHEAS and testosterone secretion and the increase in cortisol are associated with a rise of frailty and mortality.
OBJECTIVE
To investigate the association of DHEAS, cortisol and testosterone plasma levels with S-Klotho plasma levels in healthy sedentary middle-aged adults.
METHODS
73 (39 women) healthy middle-aged sedentary adults (45-65 years old) were recruited for the present study. The blood samples were collected in the morning after fasting for 12 h.
RESULTS
DHEAS was positively associated with S-Klotho in men (β = 0.521, R = 0.248, P = 0.002), whereas no association was observed in women (P ≥ 0.201). Testosterone was positively associated with S-Klotho in both men and women (β = 0.360, R = 0.099, P = 0.047; β = 0.431, R = 0.161, P = 0.010, respectively). No association was found between cortisol and S-Klotho neither in men nor in women (all P ≥ 0.141). The association between DHEAS and testosterone with S-Klotho in men disappeared after adjusting by age (all P ≥ 0.151). Nevertheless, the association between testosterone (β = 0.397, R = 0.423, P = 0.011) and S-Klotho in women remained after adjusting by age.
CONCLUSIONS
DHEAS and testosterone were positively associated with S-Klotho in healthy sedentary middle-aged men while only testosterone was positively associated in women.
背景
α-Klotho 是一种最近发现的基因，当其被破坏时会加速衰老，而过表达时会延长寿命。DHEAS 和睾酮分泌的年龄相关性下降以及皮质醇的增加与虚弱和死亡率的上升有关。
目的
研究健康久坐的中年成年人的 DHEAS、皮质醇和睾酮血浆水平与 S-Klotho 血浆水平之间的关系。
方法
本研究招募了 73 名（39 名女性）健康的中年久坐成年人（45-65 岁）。在禁食 12 小时后，于早上采集血液样本。
结果
在男性中，DHEAS 与 S-Klotho 呈正相关（β=0.521，R=0.248，P=0.002），而在女性中则没有观察到这种相关性（P≥0.201）。在男性和女性中，睾酮与 S-Klotho 呈正相关（β=0.360，R=0.099，P=0.047；β=0.431，R=0.161，P=0.010）。在男性和女性中，皮质醇与 S-Klotho 之间均未发现相关性（所有 P≥0.141）。在调整年龄后，男性中 DHEAS 和睾酮与 S-Klotho 之间的关联均消失（所有 P≥0.151）。然而，在调整年龄后，女性中睾酮（β=0.397，R=0.423，P=0.011）与 S-Klotho 之间的关联仍然存在。
结论
在健康的久坐中年男性中，DHEAS 和睾酮与 S-Klotho 呈正相关，而在女性中仅与睾酮呈正相关。
Zotero 插件