Department of Medical Physiology, School of Medicine, University of Granada, Spain.
Department of Medical Physiology, School of Medicine, University of Granada, Spain; PROmoting FITness and Health through Physical Activity Research Group (PROFITH), Department of Physical Education and Sports, Faculty of Sport Sciences, University of Granada, Spain.
Drug Alcohol Depend. 2019 Jan 1;194:107-111. doi: 10.1016/j.drugalcdep.2018.09.024. Epub 2018 Nov 3.
Alcohol consumption is related to several diseases and injuries that accelerate the ageing process and increase the mortality and morbidity risk. The soluble form of the α-Klotho gene (called S-Klotho) is widely considered as a powerful anti-ageing biomarker.
The aim of the present study was to analyze the association between alcohol consumption and S-Klotho plasma levels in sedentary middle-aged adults.
74 (39 women) middle-aged sedentary adults (40-65 years old) participated in the present study. Alcohol consumption was assessed with a food frequency questionnaire previously validated and with three non-consecutive 24-hours recall. The S-Klotho plasma levels were measured by ELISA using a soluble α-Klotho ELISA assay kit.
Total alcoholic drinks consumption was negatively associated with S-Klotho plasma levels (β=-17.031; R = 0.096, P = 0.013). Furthermore, we observed that higher consumption of total alcoholic drinks is associated with lower S-Klotho plasma levels in middle-aged sedentary adults controlling for BMI (β=-16.372; R = 0.201, P = 0.011), LMI (β=-31.854; R = 0.305, P = 0.010) and for FMI β=-13.337; R = 0.075, P = 0.049).
In conclusion, our study shows that total alcoholic drinks consumption is negatively associated with the S-Klotho plasma levels in middle-aged sedentary adults.
饮酒与多种疾病和损伤有关，这些疾病和损伤会加速衰老过程，增加死亡率和发病率风险。α-Klotho 基因的可溶性形式（称为 S-Klotho）被广泛认为是一种强大的抗衰老生物标志物。
本研究旨在分析饮酒与久坐中年成年人 S-Klotho 血浆水平之间的关系。
本研究纳入了 74 名（39 名女性）久坐的中年成年人（40-65 岁）。使用先前经过验证的食物频率问卷和三次非连续 24 小时回忆法评估饮酒情况。使用可溶性 α-Klotho ELISA 试剂盒通过 ELISA 测量 S-Klotho 血浆水平。
总酒精饮料摄入量与 S-Klotho 血浆水平呈负相关（β=-17.031；R²=0.096，P=0.013）。此外，我们观察到，在控制 BMI（β=-16.372；R²=0.201，P=0.011）、LMI（β=-31.854；R²=0.305，P=0.010）和 FMI 后，总酒精饮料摄入量较高与中年久坐成年人的 S-Klotho 血浆水平较低相关β=-13.337；R²=0.075，P=0.049）。
总之，我们的研究表明，总酒精饮料摄入量与中年久坐成年人的 S-Klotho 血浆水平呈负相关。
