Southeast Poultry Research Laboratory, US National Poultry Research Center, Agricultural Research Service, USDA, 934 College Station Dr., Athens, GA 30605, USA.
Southeast Poultry Research Laboratory, US National Poultry Research Center, Agricultural Research Service, USDA, 934 College Station Dr., Athens, GA 30605, USA; University of Sao Paulo, ZMV, FZEA, Pirassununga, São Paulo 13635-900, Brazil.
Virology. 2019 May;531:203-218. doi: 10.1016/j.virol.2019.03.010. Epub 2019 Mar 22.
In May of 2018, virulent Newcastle disease virus was detected in sick, backyard, exhibition chickens in southern California. Since, the virus has affected 401 backyard and four commercial flocks, and one live bird market in California, and one backyard flock in Utah. The pathogenesis and transmission potential of this virus, along with two genetically related and widely studied viruses, chicken/California/2002 and chicken/Belize/2008, were evaluated in both 3-week- and 62-week-old chickens given a low, medium, or high challenge dose. All three viruses were highly virulent causing clinical signs, killing all the chickens in the medium and high dose groups, and efficiently transmitting to contacts. The three viruses also replicated in the reproductive tract of the adult hens. Virus shedding for all viruses was detected 24 hours after challenge, peaking with high titers at day 4 post challenge. Although not genetically identical, the studied isolates were shown to be phenotypically very similar, which allows the utilization of the available literature in the control of the current outbreak.
2018 年 5 月，在美国加利福尼亚州南部，后院饲养的展览鸡群中出现了高致病性新城疫病毒。此后，该病毒已影响到加利福尼亚州的 401 个后院饲养场和 4 个商业饲养场，以及加利福尼亚州的一个活禽市场和犹他州的一个后院饲养场。研究人员评估了这种病毒以及两种遗传上相关且广泛研究的病毒（鸡/加利福尼亚/2002 株和鸡/伯利兹/2008 株）在 3 周龄和 62 周龄鸡群中的发病机制和传播潜力，这些鸡群接受了低、中、高剂量的病毒挑战。这三种病毒都具有高度的致病性，导致临床症状出现，中、高剂量组的所有鸡都死亡，并能有效地传播给接触者。这三种病毒还能在成年母鸡的生殖道中复制。所有病毒的病毒脱落都在攻毒后 24 小时内被检测到，在攻毒后第 4 天达到高滴度峰值。尽管这些分离株在遗传上并不完全相同，但在表型上非常相似，这使得可以利用现有的文献来控制当前的疫情。
