1998年哈萨克斯坦新城疫病毒爆发期间鸡源强毒新城疫病毒分离株的分子特征分析
Molecular characterization of virulent Newcastle disease virus isolates from chickens during the 1998 NDV outbreak in Kazakhstan.
作者信息
Bogoyavlenskiy Andrey, Berezin Vladimir, Prilipov Alexey, Usachev Eugeniy, Lyapina Olga, Levandovskaya Svetlana, Korotetskiy Ilya, Tolmacheva Valentina, Makhmudova Nailya, Khudyakova Svetlana, Tustikbaeva Gulnur, Zaitseva Irina, Omirtaeva Elmira, Ermakova Olga, Daulbaeva Klara, Asanova Saule, Kydyrmanov Aydyn, Sayatov Marat, King Daniel
机构信息
Institute of Microbiology & Virology, Bogenbay batyr Street, 103, 480100, Almaty, Kazakhstan.
出版信息
Virus Genes. 2005 Aug;31(1):13-20. doi: 10.1007/s11262-004-2195-2.
Newcastle disease virus (NDV) infects domesticated and wild birds throughout the world and has the possibility to cause outbreaks in chicken flocks in future. To assess the evolutionary characteristics of 10 NDV strains isolated from chickens in Kazakhstan during 1998 we investigated the phylogenetic relationships among these viruses and viruses described previously. For genotyping, fusion (F) gene phylogenetic analysis (nucleotide number 47-421) was performed using sequences of Kazakhstanian isolates as compared to sequences of selected NDV strains from GenBank. Phylogenetic analysis showed that all newly characterized strains belonged to the genetic group designated as VIIb. All strains possessed a virulent fusion cleavage site (RRQRR/F) belonging to velogenic or mesogenic pathotypes with intracerebral pathogenicity indexes (ICPI) varying from 1.05 to 1.87.
新城疫病毒（NDV）感染世界各地的家禽和野鸟，未来有可能在鸡群中引发疫情。为评估1998年从哈萨克斯坦鸡群中分离出的10株新城疫病毒（NDV）毒株的进化特征，我们研究了这些病毒与先前描述的病毒之间的系统发育关系。为进行基因分型，使用哈萨克斯坦分离株的序列与来自GenBank的选定新城疫病毒（NDV）毒株序列进行比较，对融合（F）基因进行系统发育分析（核苷酸编号47 - 421）。系统发育分析表明，所有新鉴定的毒株都属于指定为VIIb的遗传组。所有毒株都具有属于速发型或中发型致病型的强毒融合裂解位点（RRQRR/F），脑内致病指数（ICPI）在1.05至1.87之间变化。
Zotero 插件