Park Kang Min, Lee Byung In, Kim Sung Eun
Departments of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea.
Departments of Neurology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, Republic of Korea,
Eur Neurol. 2018;80(5-6):345-354. doi: 10.1159/000496511. Epub 2019 Mar 29.
We evaluated a brain network using graph theoretical analysis and microstructural abnormalities of the white matter in patients with transient global amnesia (TGA).
Twenty patients with TGA and healthy control subjects were recruited, and they underwent diffusion tensor imaging (DTI) scans. Graph theory was applied to obtain network measures based on DTI data. We investigated the network measures and microstructural abnormalities of white matter using tract-based spatial statistics (TBSS) analysis in the patients with TGA.
Measures of global topology were not different between the patients with TGA and healthy subjects. However, there were significant differences of hubs organization; the strength of the right superior and inferior orbitofrontal, the right inferior frontal operculum, the left superior parietal, and left postcentral gyrus, the cluster coefficient of the right middle orbitofrontal and left inferior parietal gyrus, the betweenness centrality of the left angular gyrus, and the pagerank centrality of the right superior and inferior orbitofrontal, right inferior frontal operculum, left superior parietal, and left postcentral gyrus in the patients with TGA were significantly lower than those in healthy subjects. Regarding the analysis of the white matter microstructure with TBSS, there were no differences in the fractional anisotropy and mean diffusivity values between the 2 groups.
We newly identify a reorganization of network hubs of the brain network in patients with TGA, especially in the regions of the default-mode network. These alterations of the brain network may play a role in the pathophysiologic mechanism underlying TGA and suggest that TGA is a network disease.
我们使用图论分析和短暂性全面性遗忘症（TGA）患者白质的微观结构异常来评估脑网络。
招募了20名TGA患者和健康对照者，他们接受了扩散张量成像（DTI）扫描。应用图论基于DTI数据获得网络测量值。我们使用基于纤维束的空间统计学（TBSS）分析来研究TGA患者的网络测量值和白质微观结构异常。
TGA患者和健康受试者之间的全局拓扑测量值没有差异。然而，在枢纽组织方面存在显著差异；TGA患者右侧眶额上回和下回、右侧额下回岛盖部、左侧顶上叶和左侧中央后回的强度，右侧眶额中回和左侧顶下叶的聚类系数，左侧角回的介数中心性，以及右侧眶额上回和下回、右侧额下回岛盖部、左侧顶上叶和左侧中央后回的PageRank中心性均显著低于健康受试者。关于用TBSS对白质微观结构的分析，两组之间的各向异性分数和平均扩散率值没有差异。
我们首次发现TGA患者脑网络枢纽的重新组织，特别是在默认模式网络区域。脑网络的这些改变可能在TGA潜在的病理生理机制中起作用，并表明TGA是一种网络疾病。
