Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
J Am Acad Dermatol. 2019 Dec;81(6):1358-1370. doi: 10.1016/j.jaad.2019.03.070. Epub 2019 Mar 29.
Human papillomavirus (HPV) causes cervical cancer, anal cancer, vulvar cancer, vaginal cancer, penile cancer, and oropharyngeal cancer. Squamous cell carcinoma (SCC) in the genital region in particular is recognized to be caused by HPV infection, and intraepithelial lesions of the penis and vulva are termed penile intraepithelial neoplasia and vulvar intraepithelial neoplasia, respectively. Although SCC of the nail apparatus is recognized as being associated with high-risk HPVs, it is not well-known in general medicine, and its analysis has been insufficient. In this article, we reviewed 136 cases of HPV-associated nail SCC and SCC in situ and delineated their clinical characteristics. We found that half of the cases were high-risk HPV-associated. Almost all of the types were high-risk α-HPVs. This disease had a male dominance and left hand digit 3 and right hand digits 1-3 were typically affected. In this review, 24% of the cases of nail SCC had a history of other HPV-associated diseases, suggesting the possibility of genitodigital transmission. We propose that nail SCC is a hidden high-risk HPV-associated reservoir and should be recognized as a sexually transmitted infection.
人乳头瘤病毒（HPV）可引起宫颈癌、肛门癌、外阴癌、阴道癌、阴茎癌和口咽癌。特别是生殖器部位的鳞状细胞癌（SCC）被认为是由 HPV 感染引起的，而阴茎和外阴的上皮内病变分别称为阴茎上皮内瘤变和外阴上皮内瘤变。尽管甲装置 SCC 被认为与高危 HPV 有关，但在一般医学中并不常见，其分析也不足。在本文中，我们回顾了 136 例 HPV 相关的指甲 SCC 和 SCC 原位，并描述了它们的临床特征。我们发现，一半的病例与高危 HPV 相关。几乎所有类型都是高危α-HPV。这种疾病男性居多，左手第 3 指和右手第 1-3 指通常受累。在这项回顾性研究中，24%的指甲 SCC 病例有其他 HPV 相关疾病的病史，提示存在生殖器-手指传播的可能性。我们提出指甲 SCC 是一种隐匿的高危 HPV 相关储存库，应被视为性传播感染。
