屏状核是大鼠上乳头体核投射的一个靶点。

The claustrum is a target for projections from the supramammillary nucleus in the rat.

机构信息

EA481, Neurosciences Intégratives et Cliniques, UFR Santé, 19 rue Ambroise Paré, Université de Bourgogne Franche-Comté, 25030 Besançon cedex, France.

出版信息

Neuroscience. 2019 Jun 15;409:261-275. doi: 10.1016/j.neuroscience.2019.03.045. Epub 2019 Mar 28.

DOI:10.1016/j.neuroscience.2019.03.045

PMID:30930128

Abstract

Injection of the anterograde tracer Phaseolus vulgaris leucoagglutinin (PHAL) into the rat rostral and caudal supramammillary nucleus (SUM) provided expected patterns of projections into the hippocampus and the septal region. In addition, unexpectedly intense projections were observed into the claustrum defined by parvalbumin expression. Injections of the retrograde tracer fluorogold (FG) into the hippocampus and the region of the claustrum showed that the cells of origin of these projections distributed similarly within the borders of the SUM. The SUM is usually involved in control of hippocampal theta activity, but the observation of intense projections into the claustrum indicates that it may also influence isocortical processes. Therefore, the SUM may coordinate sensory processing in the isocortex with memory formation in the hippocampus.

摘要

将顺行示踪剂菜豆植物凝集素（PHA-L）注射到大鼠额侧和尾侧上乳突核（SUM）中，提供了预期的投射到海马体和隔区的模式。此外，出乎意料的是，在表达巴尔蛋白的屏状核中观察到强烈的投射。将逆行示踪剂荧光金（FG）注射到海马体和屏状核区域表明，这些投射的起源细胞在 SUM 的边界内分布相似。SUM 通常参与控制海马体θ活动，但观察到强烈的投射到屏状核表明它也可能影响同型皮质过程。因此，SUM 可能协调同型皮质中的感觉处理与海马体中的记忆形成。