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痉挛性发音障碍患者发声时非典型体感运动皮质反应。

Atypical somatosensory-motor cortical response during vowel vocalization in spasmodic dysphonia.

机构信息

Human Sensorimotor Control Laboratory, School of Kinesiology, University of Minnesota, United States.

Human Sensorimotor Control Laboratory, School of Kinesiology, University of Minnesota, United States.

出版信息

Clin Neurophysiol. 2019 Jun;130(6):1033-1040. doi: 10.1016/j.clinph.2019.03.003. Epub 2019 Mar 23.

DOI:10.1016/j.clinph.2019.03.003
PMID:30930193
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7251941/
Abstract

OBJECTIVE

Spasmodic dysphonia (SD) is a debilitating voice/speech disorder without an effective cure. To obtain a better understanding of the underlying cortical neural mechanism of the disease we analyzed electroencephalographic (EEG) signals of people with SD during voice production.

METHOD

Ten SD individuals and 10 healthy volunteers produced 50 vowel vocalization epochs of 2500 ms duration. Two EEG features were derived: (1) event-related change in spectral power during vocalization relative to rest, (2) inter-regional spectral coherence.

RESULTS

During early vocalization (500-1000 ms) the SD group showed significantly larger alpha band spectral power over the left motor cortex. During late vocalization (1000-2500 ms) SD patients showed a significantly larger gamma band coherence between left somatosensory and premotor cortical areas.

CONCLUSIONS

Two atypical patterns of cortical activity characterize the pathophysiology of spasmodic dysphonia during voice production: (1) a reduced movement-related desynchronization of motor cortical networks, (2) an excessively large synchronization between left somatosensory and premotor cortical areas.

SIGNIFICANCE

The pathophysiology of SD is characterized by an abnormally high synchronous activity within and across cortical neural networks involved in voice production that is mainly lateralized in the left hemisphere.

摘要

目的

痉挛性发音障碍（SD）是一种使人衰弱的声音/言语障碍，目前尚无有效的治疗方法。为了更好地了解这种疾病的皮质神经潜在机制，我们分析了 SD 患者在发声时的脑电图（EEG）信号。

方法

10 名 SD 个体和 10 名健康志愿者产生了持续 2500ms 的 50 个元音发声时期。得出了两个 EEG 特征：（1）发声时相对于休息时的频谱功率的相关变化，（2）区域间频谱相干性。

结果

在早期发声（500-1000ms）期间，SD 组在左运动皮质上显示出明显更大的 alpha 频带频谱功率。在晚期发声（1000-2500ms）期间，SD 患者在左躯体感觉和运动前皮质区域之间表现出明显更大的伽马带相干性。

结论

在发声过程中，SD 的皮质活动有两种非典型模式：（1）运动皮质网络的运动相关去同步化减少，（2）左躯体感觉和运动前皮质区域之间的过度同步化。

意义

SD 的病理生理学特征是发声过程中涉及的皮质神经网络内和跨皮质神经网络的异常高同步活动，主要偏侧化在左半球。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f4e/7251941/2d12f8d99301/nihms-1525875-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f4e/7251941/13c5c69202be/nihms-1525875-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f4e/7251941/7959999f1058/nihms-1525875-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f4e/7251941/2d12f8d99301/nihms-1525875-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f4e/7251941/13c5c69202be/nihms-1525875-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f4e/7251941/7959999f1058/nihms-1525875-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f4e/7251941/2d12f8d99301/nihms-1525875-f0003.jpg

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