van Eys J
Cancer. 1986 Oct 15;58(8 Suppl):1874-80. doi: 10.1002/1097-0142(19861015)58:8+<1874::aid-cncr2820581414>3.0.co;2-f.
The physiologic consequences of malnutrition in children with cancer are reviewed. It is stressed that the child with cancer has a nutritional state that is no different from the average population from which the child comes. What little malnutrition is seen is calorie malnutrition. The physiologic consequences are those seen in any malnourished patient. Once the patient is being treated for cancer and the cancer course has progressed, the complications of chemotherapy and radiotherapy add to the difficulty in interpretation. However, the problem of decreased resistance to infection is one of the major problems that result from this malnutrition. The one nutrient found deficient in children with cancer is iron. Because transferrin is sensitive to prolonged protein malnutrition and because of the high level of ferritin in children with certain cancers, interpretation of laboratory values defining iron deficiency is difficult and iron homeostasis may well be very deranged.
本文综述了癌症患儿营养不良的生理后果。强调患有癌症的儿童的营养状况与该儿童所属的普通人群并无差异。所观察到的少量营养不良情况为热量营养不良。其生理后果与任何营养不良患者所出现的情况相同。一旦患者开始接受癌症治疗且癌症病程进展，化疗和放疗的并发症会增加解读难度。然而，抵抗力下降易感染是这种营养不良导致的主要问题之一。在癌症患儿中发现缺乏的一种营养素是铁。由于转铁蛋白对长期蛋白质营养不良敏感，且某些癌症患儿的铁蛋白水平较高，因此难以解读确定缺铁的实验室值，而且铁稳态很可能严重紊乱。
