苦苣二氢茋B和D苷元的合成。

Synthesis of the aglycon of scorzodihydrostilbenes B and D.

作者信息

Weimann Katja, Braun Manfred

机构信息

Institute of Organic and Macromolecular Chemistry, Heinrich-Heine-University Düsseldorf, Universitätsstr. 1, D-40225 Düsseldorf, Germany.

出版信息

Beilstein J Org Chem. 2019 Mar 6;15:610-616. doi: 10.3762/bjoc.15.56. eCollection 2019.

DOI:10.3762/bjoc.15.56

PMID:30931002

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6423597/

Abstract

Benzyl- and methyl-protected 2,4-dihydroxyacetophenones are added under ruthenium catalysis to 4-methoxy- and 3,4-dimethoxystyrene in a completely regioselective manner. Thus, oxygenated dihydrostilbenes are obtained that feature the skeleton of scorzodihydrostilbenes - antioxidative agents that were recently isolated from . Selective deprotection liberates the corresponding phenols, among them the aglycon of scorzodihydrostilbenes B and D.

摘要

在钌催化下，苄基和甲基保护的2,4 - 二羟基苯乙酮以完全区域选择性的方式添加到4 - 甲氧基和3,4 - 二甲氧基苯乙烯中。由此得到了具有scorzodihydrostilbenes骨架的氧化二氢茋类化合物，scorzodihydrostilbenes是最近从……中分离出的抗氧化剂。选择性脱保护释放出相应的酚类，其中包括scorzodihydrostilbenes B和D的苷元。