Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
J Am Chem Soc. 2011 Jan 26;133(3):400-2. doi: 10.1021/ja108809u. Epub 2010 Dec 15.
Cobalt-phosphine and cobalt-carbene catalysts have been developed for the hydroarylation of styrenes via chelation-assisted C-H bond activation, to afford branched and linear addition products, respectively, in a highly regioselective fashion. Deuterium-labeling experiments suggested a mechanism involving reversible C-H bond cleavage and olefin insertion steps and reductive elimination as the rate- and regioselectivity-determining step.
钴-膦和钴-卡宾催化剂已被开发用于通过螯合辅助 C-H 键活化的苯乙烯的加氢芳基化，分别以高度区域选择性的方式得到支链和直链加成产物。氘标记实验表明，该反应涉及可逆的 C-H 键断裂和烯烃插入步骤，以及还原消除作为速率和区域选择性决定步骤的反应机理。
