Adamiak-Godlewska Aneta, Skorupska Katarzyna, Rechberger Tomasz, Romanek-Piva Katarzyna, Miotła Paweł
2nd Department of Gynecology, Medical University in Lublin, ul. Jaczewskiego 8, 20-954 Lublin, Poland.
Biomed Res Int. 2019 Feb 25;2019:2360185. doi: 10.1155/2019/2360185. eCollection 2019.
HYPOTHESIS/AIMS OF STUDY: Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is the second most common cause of primary amenorrhea. The ESHRE/ESGE categorizes this disorder within the class 5 uterine malformation of the female genital tract anomalies. It is characterized by congenital absence of the uterus, cervix, and upper part of the vagina in otherwise phenotypically normal 46XX females. These patients have normal ovaries, biphasic ovarian cycle, and female psychosexual identification. Laparoscopic Vecchietti's operation-surgical method in which the vagina increases in size by gradually applying traction to the vaginal vault-is one of the methods used to treat MRKH. The aim of this study was to establish the urogynecological and sexual functions after Vecchietti's operation.
Fifteen patients with MRKHS who underwent laparoscopic Vecchietti's operation were included. A control group of 15 age-matched, childless, sexually active women were examined during the same period. All patients underwent the basic evaluation of anatomical outcomes. Sexual outcomes were established by the Polish validated Female Sexual Function Index (FSFI) questionnaire. Continence status was assessed by Polish validated Urinary Distress Inventory (UDI-6) and the Incontinence Impact Questionnaire (IIQ-7).
Mean age of MRKH group was 22.06±5.13 yrs. Mean follow-up after surgery was 8.02±3.43 yrs. Mean age of women from control group was 22.4±4.35. Mean FSFI scores show good quality of sexual life in both groups. UDI-6 scores showed that patients after Vecchietti surgery have urogynecological problems significantly more often than healthy women do. Based on the IIQ-7, it is evident that one patient from the MRKH group (6,6%) suffers from stress urinary incontinence and the rest (20%) have rather irritative problems with the functioning of the lower urinary tract.
Quality of sexual life after the Vecchietti's operation in long-term follow-up does not differ from that of healthy women, but these patients suffer more frequent from urogynecological complaints. The trial is registered with NCT03809819.
研究假设/目的:迈耶-罗基坦斯基-库斯特-豪泽(MRKH)综合征是原发性闭经的第二大常见病因。欧洲人类生殖与胚胎学会/欧洲妇科内镜学会将这种疾病归类为女性生殖道畸形的5类子宫畸形。其特征是在表型正常的46XX女性中先天性子宫、宫颈和阴道上段缺失。这些患者卵巢正常,卵巢周期呈双相,具有女性心理性别认同。腹腔镜维凯蒂手术——一种通过逐渐对阴道穹窿施加牵引力来增大阴道尺寸的手术方法——是用于治疗MRKH的方法之一。本研究的目的是确定维凯蒂手术后的泌尿妇科和性功能情况。
研究设计、材料与方法:纳入15例接受腹腔镜维凯蒂手术的MRKHS患者。同期检查了15名年龄匹配、未育、有性生活的女性作为对照组。所有患者均接受了解剖学结果的基本评估。通过波兰验证的女性性功能指数(FSFI)问卷确定性功能结果。通过波兰验证的排尿困扰量表(UDI-6)和尿失禁影响问卷(IIQ-7)评估控尿状态。
MRKH组的平均年龄为22.06±5.13岁。术后平均随访时间为8.02±3.43年。对照组女性的平均年龄为22.4±4.35岁。平均FSFI评分显示两组的性生活质量都较好。UDI-6评分显示,维凯蒂手术后的患者泌尿妇科问题明显比健康女性更常见。基于IIQ-7,很明显MRKH组中有1名患者(6.6%)患有压力性尿失禁,其余患者(20%)下尿路功能存在刺激性问题。
维凯蒂手术后长期随访的性生活质量与健康女性无异,但这些患者泌尿妇科问题更常见。该试验已在ClinicalTrials.gov注册,注册号为NCT03809819。