Ciavarella D, Lavallo E, Reiss R F
Clin Lab Haematol. 1986;8(3):233-42. doi: 10.1111/j.1365-2257.1986.tb00100.x.
The in vitro and in vivo recovery of coagulation factor activity in platelet concentrates stored up to 172 h was studied. In vitro studies revealed that fibrinogen and antithrombin III levels do not change with storage. Factors II, V, VII, VIII, IX, X and XI all showed statistically significant falls from baseline over the 172 h storage period. However, most factor activities remained above 70%, with the major exception of factors V and VIII. These factors fell to less than 30% activity over the storage period, consistent with their known lability during whole blood storage. In vivo studies after platelet concentrate infusion in patients with concurrent thrombocytopenia and coagulation deficiencies revealed that the measured in vitro activity was recoverable in vivo. We conclude that platelet concentrates stored for 172 h are an adequate source of clotting factors. However, like stored whole blood, they may not provide therapeutic doses of factors V and VIII.
研究了储存长达172小时的血小板浓缩物中凝血因子活性的体外和体内恢复情况。体外研究表明，纤维蛋白原和抗凝血酶III水平在储存过程中没有变化。在172小时的储存期内，因子II、V、VII、VIII、IX、X和XI的水平均较基线有统计学意义的下降。然而，大多数因子活性仍保持在70%以上，主要例外是因子V和VIII。在储存期内，这些因子的活性降至30%以下，这与它们在全血储存期间已知的不稳定性一致。对同时患有血小板减少症和凝血缺陷的患者输注血小板浓缩物后的体内研究表明，体外测得的活性在体内是可恢复的。我们得出结论，储存172小时的血小板浓缩物是凝血因子的充足来源。然而，与储存的全血一样，它们可能无法提供治疗剂量的因子V和VIII。
