Impicciatore M, Morini G, Chiavarini M, Barocelli E
Eur J Pharmacol. 1986 Jul 15;126(1-2):53-60. doi: 10.1016/0014-2999(86)90737-5.
In the present paper the gastric secretory and motor responsiveness to a gastrin-like peptide, caerulein, was assessed in rats with a chronic gastric ulcer induced by 'isolation', 48 h after completing prolonged treatments (30 and 60 days) with cimetidine (80 and 160 mg/kg), pirenzepine (8 and 16 mg/kg) and sulglycotide (160 mg/kg) administered orally as a single daily dose. After a 30 day pretreatment with both doses of cimetidine, gastric acid secretion was inhibited and the pylorus spasmogenic activity induced by caerulein was enhanced. The gastric effects of the peptide were not modified by pirenzepine pretreatment while an antisecretory action was shown by sulglycotide after the completion of prolonged treatment (60 days). The ulcers were significantly reduced by cimetidine (low dose) and sulglycotide after 30 day pretreatment. The effects are more likely to be related to the treatment than to the presence of the drugs on gastric receptors.
在本论文中，对经“隔离”诱导形成慢性胃溃疡的大鼠，在以每日单剂量口服西咪替丁（80和160毫克/千克）、哌仑西平（8和16毫克/千克）和硫糖铝（160毫克/千克）进行长时间治疗（30天和60天）结束48小时后，评估了胃对一种胃泌素样肽——蛙皮素的分泌和运动反应性。在用两种剂量的西咪替丁进行30天预处理后，胃酸分泌受到抑制，蛙皮素诱导的幽门痉挛活性增强。哌仑西平预处理未改变该肽的胃效应，而硫糖铝在长时间治疗（60天）结束后显示出抗分泌作用。30天预处理后，西咪替丁（低剂量）和硫糖铝使溃疡显著减少。这些效应更可能与治疗有关，而非与药物在胃受体上的存在有关。
