Wang Z T, Du Q, Xu G J, Wang R J, Fu D Z, Ng T B
Department of Pharmacognosy, China Pharmaceutical University, Najing, China.
Gen Pharmacol. 1997 Mar;28(3):469-73. doi: 10.1016/s0306-3623(96)00047-x.
The action of Codonopsis pilosula extract in 5 animal models of gastric ulcer was investigated. It was found that the extract had higher efficacy on gastric ulcer induced by stress, acetic acid and sodium hydroxide and little significant effect on ulcers induced by pyloroligature and indomethacin. The C. pilosula extract was also capable of reducing gastric acid pepsin secretion. It is possible that inhibition of gastrointestinal movement and propulsion is one of the mechanisms underlying the antiulcer action of C. pilosula extract.
研究了党参提取物在5种胃溃疡动物模型中的作用。发现该提取物对由应激、乙酸和氢氧化钠诱导的胃溃疡有较高疗效，而对幽门结扎和吲哚美辛诱导的溃疡几乎没有显著作用。党参提取物还能够减少胃酸胃蛋白酶的分泌。抑制胃肠运动和推进可能是党参提取物抗溃疡作用的潜在机制之一。
