Gent J P, Bentley M, Feely M, Haigh J R
Eur J Pharmacol. 1986 Aug 22;128(1-2):9-15. doi: 10.1016/0014-2999(86)90551-0.
Slow intravenous infusion of pentylenetetrazol was used to measure the convulsive threshold in mice. The anticonvulsant effects of clobazam, clonazepam, diazepam, lorazepam, sodium phenobarbitone and sodium valproate were assessed in naive animals and compared with the effects of the same compounds in animals which had been pretreated (twice daily for 3 days) with one of the benzodiazepines or sodium valproate. Cross-tolerance was observed between all the benzodiazepines but not between benzodiazepines and sodium phenobarbitone. Animals pretreated with the benzodiazepines were cross-tolerant to valproate, but the converse was not true; nor did sodium valproate induce tolerance to itself.
采用戊四氮缓慢静脉注射法测定小鼠惊厥阈值。在未用药的动物中评估氯巴占、氯硝西泮、地西泮、劳拉西泮、苯巴比妥钠和丙戊酸钠的抗惊厥作用，并与用其中一种苯二氮䓬类药物或丙戊酸钠预处理（每日两次，共3天）的动物中相同化合物的作用进行比较。所有苯二氮䓬类药物之间均观察到交叉耐受性，但苯二氮䓬类药物与苯巴比妥钠之间未观察到交叉耐受性。用苯二氮䓬类药物预处理的动物对丙戊酸有交叉耐受性，但反之则不然；丙戊酸钠也不会诱导自身耐受性。
