Gent J P, Haigh J R
Eur J Pharmacol. 1983 Oct 14;94(1-2):155-8. doi: 10.1016/0014-2999(83)90454-5.
The anticonvulsant properties of the 1,5-benzodiazepine clobazam were studied in mice during and after chronic treatment at two different dose levels. Pentylenetetrazol given by slow intravenous infusion was used as the convulsant stimulus. Tolerance to the anticonvulsant effects was observed; this was rapid in onset and could be overcome by increasing the dose of clobazam.
在两种不同剂量水平的长期治疗期间及之后，对小鼠体内1,5 - 苯二氮䓬类药物氯巴占的抗惊厥特性进行了研究。通过缓慢静脉输注给予的戊四氮用作惊厥刺激物。观察到对其抗惊厥作用产生了耐受性；这种耐受性起效迅速，可通过增加氯巴占的剂量来克服。
