[Intraventricular administration of 6-hydroxydopamine and ascorbic acid changes 3H-GABA absorption by synaptic endings of the cerebral cortex of the rat].

Combined administration of 6-hydroxydopamine with ascorbic acid had no effect on 3H-GABA uptake in the rat cortical synaptosomes, whereas a significant increase of the latter was observed within 2 days after 6-hydroxydopamine alone. Ascorbic acid alone (20 micrograms in 20 microliter saline, bilaterally) significantly increased 3H-GABA uptake within 2 days and decreased it within 21 days. The data suggest that: catecholaminergic system may affect (directly or indirectly) cortical GABAergic neurons, and injection of ascorbic acid into lateral ventricles exerts an obvious effect on synaptosomal 3H-GABA uptake in the brain cortex.