[Intranuclear membranous inclusions in the CNS neurons of rats detectable after the administration of ascorbic acid and 6-hydroxydopamine].

Intranuclear membranous inclusions were found in neurons of the rat's cerebral cortex and caudate nucleus 2-21 days following the intraperitoneal injection of ascorbic acid (0.2 and 2.0 g/kg) or the intracisternal infusion of 6-hydroxydopamine (300 micrograms). The intranuclear inclusions were mostly round, occasionally irregular in shape, consisting of one or several concentric membranes; in addition, they were electron-lucid with the diameter of 0.2-0.5 microns, sometimes up to 1 micron. Possible relationship between the formation of intranuclear membranous inclusions and the acceleration of intranuclear metabolism, particularly lipid peroxidation processes, are discussed.