Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Clin Nucl Med. 2019 Jun;44(6):496-498. doi: 10.1097/RLU.0000000000002550.
Giant cell tumor of tendon sheath (GCTTS) is benign mesenchymal neoplasm, and it rarely induces hypophosphatemia. We report a 49-year-old woman with suspicious tumor-induced osteomalacia underwent Ga-DOTA-TATE PET/CT to identify potential causative tumor, which showed a hypermetabolic soft tissue nodule in the right foot. Pathology confirmed it as GCTTS following surgical resection. The patient's symptoms improved rapidly, and the serum phosphate normalized after surgery, which supports the diagnosis of tumor-induced osteomalacia. Our case showed GCTTS can be rich of somatostatin receptor and cause osteomalacia.
腱鞘巨细胞瘤（GCTTS）是良性间叶性肿瘤，很少引起低磷血症。我们报告了一例 49 岁女性，因疑似肿瘤相关性骨软化症而行 Ga-DOTA-TATE PET/CT 以确定潜在的致病肿瘤，结果显示右脚存在高代谢性软组织结节。术后病理证实为 GCTTS。患者的症状迅速改善，术后血清磷恢复正常，支持肿瘤相关性骨软化症的诊断。本病例表明 GCTTS 可以富含生长抑素受体并导致骨软化症。
