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1
Effect of enprostil, a synthetic prostaglandin E2 on 24 hour intragastric acidity, nocturnal acid and pepsin secretion.合成前列腺素E2恩前列素对24小时胃内酸度、夜间胃酸及胃蛋白酶分泌的影响。
Gut. 1986 Sep;27(9):1054-7. doi: 10.1136/gut.27.9.1054.
2
Enprostil, a synthetic prostaglandin E2 analogue, inhibits meal-stimulated gastric acid secretion and gastrin release in patients with duodenal ulcer.恩前列素，一种合成的前列腺素E2类似物，可抑制十二指肠溃疡患者进食刺激后的胃酸分泌和胃泌素释放。
Am J Med. 1986 Aug 18;81(2A):44-9. doi: 10.1016/s0002-9343(86)80010-9.
3
Twenty-four-hour intragastric acidity and clinical trial of bedtime enprostil 70 micrograms compared with ranitidine 300 mg in duodenal ulcer.
Aliment Pharmacol Ther. 1987 Apr;1(2):161-6. doi: 10.1111/j.1365-2036.1987.tb00615.x.
4
Antisecretory and serum gastrin lowering effect of enprostil in patients with duodenal ulcer disease.恩前列素对十二指肠溃疡病患者的抗分泌及降低血清胃泌素作用
Gastroenterology. 1985 Sep;89(3):555-61. doi: 10.1016/0016-5085(85)90451-2.
5
A synthetic prostaglandin E2 analogue, enprostil, hastens gastric emptying of solids in patients with an active duodenal ulcer.
Scand J Gastroenterol. 1990 Nov;25(11):1118-22. doi: 10.3109/00365529008998543.
6
Effect of a single oral dose of enprostil on gastric secretion and gastrin release. Studies in healthy volunteers and patients with pernicious anemia.单次口服恩前列素对胃酸分泌和胃泌素释放的影响。对健康志愿者和恶性贫血患者的研究。
Am J Med. 1986 Aug 18;81(2A):40-3. doi: 10.1016/s0002-9343(86)80009-2.
7
Treatment of duodenal ulcer with enprostil, a synthetic prostaglandin E2 analogue.用恩前列素（一种合成前列腺素E2类似物）治疗十二指肠溃疡。
Am J Med. 1986 Aug 18;81(2A):59-63. doi: 10.1016/s0002-9343(86)80013-4.
8
Treatment of duodenal ulcer with enprostil, a prostaglandin E2 analogue.用恩前列素（一种前列腺素E2类似物）治疗十二指肠溃疡。
Am J Med. 1986 Aug 18;81(2A):64-8. doi: 10.1016/s0002-9343(86)80014-6.
9
[Enprostil in the acute treatment of duodenal ulcer: direct comparative study with pirenzepin].恩前列素用于十二指肠溃疡的急性治疗：与哌仑西平的直接对比研究
Z Gastroenterol. 1986 May;24(5):257-61.
10
[Evaluation of the efficacy and tolerance of enprostil, synthetic analog of prostaglandin E2, in a clinical study in double-blind vs. placebo].[在一项双盲对照安慰剂的临床研究中评估前列腺素E2的合成类似物恩前列素的疗效和耐受性]
Clin Ter. 1988 Jun 15;125(5):337-43.

引用本文的文献

1
Enprostil. A preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of peptic ulcer disease.恩前列素。对其药效学、药代动力学特性以及治疗消化性溃疡疾病的疗效的初步综述。
Drugs. 1987 Nov;34(5):539-59. doi: 10.2165/00003495-198734050-00003.

本文引用的文献

1
Kinetic assay of human pepsin with albumin-bromphenol blue as substrate.以白蛋白-溴酚蓝为底物对人胃蛋白酶进行动力学分析。
Clin Chem. 1983 Mar;29(3):447-51.
2
Single nocturnal dose of an H2 receptor antagonist for the treatment of duodenal ulcer.夜间单次服用H2受体拮抗剂治疗十二指肠溃疡。
Gut. 1983 Oct;24(10):904-8. doi: 10.1136/gut.24.10.904.
3
The effects of impromidine and pentagastrin on gastric output of histamine, acid and pepsin in man.英普咪定和五肽胃泌素对人体胃组胺、胃酸和胃蛋白酶分泌量的影响。
Hepatogastroenterology. 1982 Feb;29(1):30-4.
4
Ranitidine 150 mg twice daily vs 300 mg nightly in treatment of duodenal ulcers.雷尼替丁每日两次，每次150毫克与每晚300毫克治疗十二指肠溃疡的对比研究。
Lancet. 1984 Aug 4;2(8397):274-6. doi: 10.1016/s0140-6736(84)90312-x.
5
Gastric bicarbonate secretion in humans. Effect of pentagastrin, bethanechol, and 11,16,16-trimethyl prostaglandin E2.人体胃碳酸氢盐分泌。五肽胃泌素、氨甲酰甲胆碱和11,16,16-三甲基前列腺素E2的作用。
J Clin Invest. 1983 Jul;72(1):295-303. doi: 10.1172/jci110969.
6
The effect of secretin, glucagon, and duodenal acidification on pepsin secretion in man.促胰液素、胰高血糖素及十二指肠酸化对人体胃蛋白酶分泌的影响。
Gastroenterology. 1969 Aug;57(2):159-62.
7
pH stability and activity curves of pepsin with special reference to their clinical importance.胃蛋白酶的pH稳定性和活性曲线及其临床重要性
Gut. 1965 Oct;6(5):506-8. doi: 10.1136/gut.6.5.506.
8
Cobalamin-specific R binder in pernicious anemia gastric juice: production by digestive enzyme action on saliva R binder.恶性贫血胃液中钴胺素特异性R结合蛋白：由消化酶对唾液R结合蛋白的作用产生。
Am J Gastroenterol. 1985 Nov;80(11):841-52.
9
Smoking, gastric secretion, and inhibition by H2 receptor antagonists.吸烟、胃分泌以及H2受体拮抗剂的抑制作用。
Lancet. 1985 May 4;1(8436):1049. doi: 10.1016/s0140-6736(85)91654-x.
10
Nocturnal doses of H2 receptor antagonists for duodenal ulcer.十二指肠溃疡夜间服用H2受体拮抗剂。
Lancet. 1985 Mar 16;1(8429):647-8. doi: 10.1016/s0140-6736(85)92196-8.

合成前列腺素E2恩前列素对24小时胃内酸度、夜间胃酸及胃蛋白酶分泌的影响。

Effect of enprostil, a synthetic prostaglandin E2 on 24 hour intragastric acidity, nocturnal acid and pepsin secretion.

作者信息

Deakin M, Ramage J, Paul A, Gray S P, Billings J, Williams J G

出版信息

Gut. 1986 Sep;27(9):1054-7. doi: 10.1136/gut.27.9.1054.

DOI:10.1136/gut.27.9.1054
PMID:3093317
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1433785/
Abstract

We have studied the effect of a prostaglandin E2 analogue (enprostil), on intragastric acidity, gastric acid and pepsin outputs during a 24 hour period in nine patients with duodenal ulcer in remission. Enprostil 35 micrograms bd dose inhibited 24 hour intragastric acidity by 38% and a 70 micrograms nocturnal dose by 33%. Decrease in nocturnal pepsin secretion was both volume and concentration related.

摘要

我们研究了前列腺素E2类似物（恩前列素）对9例十二指肠溃疡缓解期患者24小时内胃内酸度、胃酸及胃蛋白酶分泌量的影响。恩前列素35微克，每日两次的剂量可使24小时胃内酸度降低38%，70微克夜间剂量可使其降低33%。夜间胃蛋白酶分泌的减少与分泌量及浓度均有关。