Prudhomme M, Dauphin G, Jeminet G
J Antibiot (Tokyo). 1986 Jul;39(7):922-33. doi: 10.7164/antibiotics.39.922.
Ten semi-synthetic analogs of A23187 (calcimycin), with only the benzoxazole ring substituents modified together with the ionophore X14885A were studied with regard to their calcium and magnesium carrier properties through an organic phase (toluene - butanol, 70:30). The results indicate that the carboxylic group and the oxazolic nitrogen, maintained in the ortho position are essential for the ionophorous properties. Further, the introduction of a substituent in place of the NHCH3 group, producing steric hindrance of the carboxylic group leads to a destabilization of the 2:1 associations with cations.
研究了A23187（钙霉素）的十种半合成类似物，这些类似物仅对苯并恶唑环取代基以及离子载体X14885A进行了修饰，通过有机相（甲苯 - 丁醇，70:30）研究了它们的钙和镁载体性质。结果表明，处于邻位的羧基和恶唑氮对于离子载体性质至关重要。此外，用取代基取代NHCH3基团，对羧基产生空间位阻，导致与阳离子的2:1缔合不稳定。
